Academic Journal
Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice.
| العنوان: | Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice. |
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| المؤلفون: | Nohara, Kazunari, Liu, Suhuan, Meyers, Matthew, S., Waget, Aurélie, Ferron, Mathieu, Karsenty, Gérard, Burcelin, Rémy, Mauvais-Jarvis, Franck |
| المساهمون: | Division of Endocrinology, Metabolism and Molecular Medicine and Comprehensive Center on Obesity, Feinberg School of Medicine, Northwestern University Evanston -Northwestern University Evanston, Department of Genetics and Development, Columbia University New York, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Division of Endocrinology, Tulane University Health Sciences Center |
| المصدر: | ISSN: 0022-0795. |
| بيانات النشر: | HAL CCSD BioScientifica |
| سنة النشر: | 2013 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | MESH: Adiposity, MESH: Androgens, MESH: Infertility, Male, MESH: Kisspeptins, MESH: Male, MESH: Mice, MESH: Motor Activity, MESH: Nerve Tissue Proteins, MESH: Neurons, MESH: Obesity, MESH: Subcutaneous Fat, Abdominal, MESH: Testosterone, MESH: Animals, Newborn, MESH: Behavior, Animal, MESH: Energy Metabolism, MESH: Environmental Pollutants, MESH: Gonadotropins, MESH: Hypogonadism, MESH: Hypothalamus, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology |
| الوصف: | International audience ; Polycystic ovary syndrome is a common endocrine disorder in females of reproductive age and is believed to have a developmental origin in which gestational androgenization programs reproductive and metabolic abnormalities in offspring. During gestation, both male and female fetuses are exposed to potential androgen excess. In this study, we determined the consequences of developmental androgenization in male mice exposed to neonatal testosterone (NTM). Adult NTM displayed hypogonadotropic hypogonadism with decreased serum testosterone and gonadotropin concentrations. Hypothalamic KiSS1 neurons are believed to be critical to the onset of puberty and are the target of leptin. Adult NTM exhibited lower hypothalamic Kiss1 expression and a failure of leptin to upregulate Kiss1 expression. NTM displayed an early reduction in lean mass, decreased locomotor activity, and decreased energy expenditure. They displayed a delayed increase in subcutaneous white adipose tissue amounts. Thus, excessive neonatal androgenization disrupts reproduction and energy homeostasis and predisposes to hypogonadism and obesity in adult male mice. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/24084835; inserm-00997962; https://inserm.hal.science/inserm-00997962; PUBMED: 24084835; PUBMEDCENTRAL: PMC3901078 |
| DOI: | 10.1530/JOE-13-0230 |
| الاتاحة: | https://inserm.hal.science/inserm-00997962 https://doi.org/10.1530/JOE-13-0230 |
| رقم الانضمام: | edsbas.36EEB615 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/JOE-13-0230 |
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