Academic Journal
Effect of Piper cubeba total extract and isolated lignans on head and neck cancer cell lines and normal fibroblasts
| العنوان: | Effect of Piper cubeba total extract and isolated lignans on head and neck cancer cell lines and normal fibroblasts |
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| المؤلفون: | Gusson-Zanetoni, Juliana Prado, da Silva, Julliene Stephanie Guaraldi Monteiro, Picão, Thais Bravo, Cardin, Laila Toniol, Prates, Janesly, Sousa, Stefanie Oliveira, Henrique, Tiago, Oliani, Sonia Maria, Tajara, Eloiza Helena, e Silva, Marcio Luis Andrade, Cunha, Nayanne Larissa, da Silva Gomes, Ana Carolina, Laurentiz, Rosangela Silva, Rodrigues-Lisoni, Flávia Cristina |
| المساهمون: | Universidade Estadual Paulista (UNESP) |
| سنة النشر: | 2022 |
| المجموعة: | Universidade Estadual Paulista São Paulo: Repositório Institucional UNESP |
| مصطلحات موضوعية: | Anti-inflammatory agents, Bioactive compounds, Phytotherapy |
| الوصف: | The objective of the present study was to evaluate the action of the crude hydroalcoholic extract of Piper cubeba fruits and isolated lignans (cubebin, dihydrocubebin, ethylcubebin, hinokinin and methylcubebin) on head and neck cancer cells. We evaluated the influence of the Piper cubeba extract and isolated lignans (10, 50 e 100 μg/mL) for 4, 24, 48 and 72 h, in the larynx (Hep-2) and oral (SCC-25) squamous cell carcinoma cells and normal fibroblasts, on morphology, cell proliferation and migration, cytotoxicity, genotoxicity and gene and protein expression (PTGS2, PTGER3, PTGER4, MMP2, MMP9). The results showed that the P. cubeba extract and different lignans do not alter the cellular morphology, but decrease cell proliferation and migration, have low cytotoxic and genotoxic effects, probably due to the alteration of the expression of genes and proteins involved with inflammatory process. From these data, we can conclude that the lignans cubebin and methylcubebin had a greater effect on head and neck cancer cells in the antiproliferative, antimigratory and genotoxic action, and could be the target of the development of new therapies including possible new drugs as a therapeutic resource for the treatment of head and neck cancer due to its immense range of biological properties. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 93-102 |
| اللغة: | English |
| تدمد: | 1347-8648 1347-8613 |
| Relation: | Journal of Pharmacological Sciences; http://dx.doi.org/10.1016/j.jphs.2021.09.002; Journal of Pharmacological Sciences, v. 148, n. 1, p. 93-102, 2022.; http://hdl.handle.net/11449/229821; 2-s2.0-85118353993 |
| DOI: | 10.1016/j.jphs.2021.09.002 |
| الاتاحة: | http://hdl.handle.net/11449/229821 https://doi.org/10.1016/j.jphs.2021.09.002 |
| رقم الانضمام: | edsbas.36D7DBD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 13478648 13478613 |
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| DOI: | 10.1016/j.jphs.2021.09.002 |