Academic Journal
Analytical and clinical evaluation of CYFRA 21-1 by electrochemiluminescent immunoassay in head and neck squamous cell carcinoma
| العنوان: | Analytical and clinical evaluation of CYFRA 21-1 by electrochemiluminescent immunoassay in head and neck squamous cell carcinoma |
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| المؤلفون: | Deng, Yan Fei, Chen, Ping, Lin, Yong Zhi, Le, Jia Zhen, Wu, Xiao Li, Yu, Ming Qiang, Zhuang, Pei Yun, Gao, Ming Hua |
| المصدر: | The Journal of Laryngology & Otology ; volume 117, issue 3, page 190-194 ; ISSN 0022-2151 1748-5460 |
| بيانات النشر: | Cambridge University Press (CUP) |
| سنة النشر: | 2003 |
| الوصف: | This paper attempts to evaluate the clinical usefulness of CYFRA 21-1 as a serum tumour marker in patients with head and neck squamous cell carcinoma (HNSCC). The serum concentration of CYFRA 21-1 was measured utilizing a new electrochemiluminescent immunoassay (ECLIA) in 142 patients with HNSCC before and after treatment, 68 patients with benign tumours of the head and neck, and 50 healthy controls. Serum levels of CYFRA 21-1 in patients with HNSCC were significantly higher than those of benign tumours and healthy controls ( p < 0.001). The diagnostic sensitivity and specificity of CYFRA 21-1 for HNSCC were 62 per cent and 100 per cent, respectively. The positive rates of CYFRA 21-1 increased with progression of HNSCC, serum CYFRA 21-1 levels were related to the tumour stage expressed by primary tumour (T) and nodal status (N) ( p < 0.001), but not related to patient age, gender, smoking and drinking habit, or histopathological grade ( p > 0.05). Post-treatment levels of CYFRA 21-1 in HNSCC decreased significantly ( p < 0.001). Among 38 patients with clinical or radiological evidence of a recurrence during follow-up, 78.9 per cent (30 of 38) showed an increase in CYFRA 21-1. The analytical ECLIA performance for serum CYFRA 21-1 provides a new means of clinical assessment for HNSCC. The results of ECLIA suggest that the serum marker CYFRA 21-1 is valuable not only for diagnosis but also for close monitoring of patients with HNSCC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1258/002221503321192485 |
| الاتاحة: | http://dx.doi.org/10.1258/002221503321192485 https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0022215103000483 |
| Rights: | https://www.cambridge.org/core/terms |
| رقم الانضمام: | edsbas.36C9E074 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1258/002221503321192485 |
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