Academic Journal
The ARIC Carotid MRI Study of Blood Cellular Markers: An Inverse Association of Monocyte Myeloperoxidase Content With Peripheral Arterial Disease
| العنوان: | The ARIC Carotid MRI Study of Blood Cellular Markers: An Inverse Association of Monocyte Myeloperoxidase Content With Peripheral Arterial Disease |
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| المؤلفون: | Matijevic, Nena, Wu, Kenneth K., Nidkarni, Nivedita, Heiss, Gerardo, Folsom, Aaron R. |
| المصدر: | Angiology, 62(3) |
| سنة النشر: | 2011 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Nuclear magnetic resonance imaging, Carotid, Carotide, Artère, Oxidoreductases, Arterial disease, Pathologie de l'appareil circulatoire, Monocito, Artery, Cardiovascular disease, Vascular disease, Enzyme, Appareil circulatoire, Artériopathie oblitérante, Blood vessel, Monocyte, Pathologie des vaisseaux sanguins, Pathologie des artères, Imagerie RMN, Circulatory system, Peroxidases, Imaginería RMN, Peroxidase, Occlusive arterial disease, Vaisseau sanguin |
| الوصف: | We evaluated the association of blood monocyte and platelet activation markers with the risk of peripheral artery disease (PAD) in a multicenter study of atherosclerosis among African American and Caucasian patients. Flow cytometric analysis of blood cells was performed in 1791 participants (209 cases with PAD and 1582 noncases) from the cross-sectional Atherosclerosis Risk in Communities Carotid Magnetic Resonance Imaging ([MRI] ARIC Carotid MRI) Study to assess platelet glycoproteins IIb and IIIa, P-selectin, CD40 ligand, platelet–leukocyte aggregates, monocyte lipopolysaccharide receptor, toll-like receptors (TLRs) 2 and 4, P-selectin glycoprotein ligand 1, cyclooxygenase 2, and myeloperoxidase. Multivariate regression analyses evaluated the association of cellular markers with the risk of PAD. After adjusting for age, race, and gender, platelet CD40L, and monocyte myeloperoxidase (mMPO) levels were significantly lower (P < .001), and monocyte TLR-4 levels were higher (P = .03) in patients with PAD. With additional adjustments for conventional risk factors, mMPO remained inversely and independently associated with the risk of PAD (odds ratio [OR]: 0.35, P = .01). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.17615/hg39-8m19; https://cdr.lib.unc.edu/downloads/hm50tz41f?file=thumbnail; https://cdr.lib.unc.edu/downloads/hm50tz41f |
| DOI: | 10.17615/hg39-8m19 |
| الاتاحة: | https://doi.org/10.17615/hg39-8m19 https://cdr.lib.unc.edu/downloads/hm50tz41f?file=thumbnail https://cdr.lib.unc.edu/downloads/hm50tz41f |
| Rights: | http://rightsstatements.org/vocab/InC/1.0/ |
| رقم الانضمام: | edsbas.36AD4FE6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/hg39-8m19 |
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