Academic Journal
Comparison of Doppler Flow Velocity and Thermodilution Derived Indexes of Coronary Physiology
| العنوان: | Comparison of Doppler Flow Velocity and Thermodilution Derived Indexes of Coronary Physiology |
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| المؤلفون: | Demir, O.M., Boerhout, C.K.M., Waard, G.A. de, Hoef, T.P. van de, Patel, N., Beijk, Marcel, Williams, R., Rahman, H., Everaars, H., Kharbanda, R.K., Knaapen, P., Royen, N. van, Piek, J.J., Perera, D. |
| المصدر: | JACC. Cardiovascular Interventions, 15, 10, pp. 1060-1070 |
| سنة النشر: | 2022 |
| المجموعة: | Radboud University: DSpace |
| مصطلحات موضوعية: | Radboudumc 16: Vascular damage RIMLS: Radboud Institute for Molecular Life Sciences |
| الوصف: | Contains fulltext : 252143.pdf (Publisher’s version ) (Open Access) ; OBJECTIVES: The aim of this study was to compare Doppler flow velocity and thermodilution-derived indexes and to determine the optimal thermodilution-based diagnostic thresholds for coronary flow reserve (CFR). BACKGROUND: The majority of clinical data and diagnostic thresholds for flow-based indexes are derived from Doppler measurements, and correspondence with thermodilution-derived indices remain unclear. METHODS: An international multicenter registry was conducted among patients who had coronary flow measurements using both Doppler and thermodilution techniques in the same vessel and during the same procedure. RESULTS: Physiological data from 250 vessels (in 149 patients) were included in the study. A modest correlation was found between thermodilution-derived CFR (CFR(thermo)) and Doppler-derived CFR (CFR(Doppler)) (r(2) = 0.36; P < 0.0001). CFR(thermo) overestimated CFR(Doppler) (mean 2.59 ± 1.46 vs 2.05 ± 0.89; P < 0.0001; mean bias 0.59 ± 1.24 by Bland-Altman analysis), the relationship being described by the equation CFR(thermo) = 1.04 × CFR(Doppler) + 0.50. The commonly used dichotomous CFR(thermo) threshold of 2.0 had poor sensitivity at predicting a CFR(Doppler) value <2.5. The optimal CFR(thermo) threshold was 2.5 (sensitivity 75.54%, specificity 81.25%). There was only a weak correlation between hyperemic microvascular resistance and index of microvascular resistance (r(2) = 0.19; P < 0.0001), due largely to variation in the measurement of flow by each modality. Forty-four percent of patients were discordantly classified as having abnormal microvascular resistance by hyperemic microvascular resistance (≥2.5 mm Hg · cm(-1) · s) and index of microvascular resistance (≥25). CONCLUSIONS: CFR calculated by thermodilution overestimates Doppler-derived CFR, while both parameters show modest correlation. The commonly used CFR(thermo) threshold of 2.0 has poor sensitivity for identifying vessels with diminished CFR, but using ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://repository.ubn.ru.nl//bitstream/handle/2066/252143/252143.pdf; https://repository.ubn.ru.nl/handle/2066/252143 |
| DOI: | 10.1016/j.jcin.2022.03.015 |
| الاتاحة: | https://repository.ubn.ru.nl//bitstream/handle/2066/252143/252143.pdf https://repository.ubn.ru.nl/handle/2066/252143 https://doi.org/10.1016/j.jcin.2022.03.015 |
| رقم الانضمام: | edsbas.368DBAB0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jcin.2022.03.015 |
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