Academic Journal
Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles
| العنوان: | Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles |
|---|---|
| المؤلفون: | Chang, Shuo-wen, Yoshihara, Toshinori, Tsuzuki, Takamasa, Natsume, Toshiharu, Kakigi, Ryo, Machida, Shuichi, Naito, Hisashi |
| المساهمون: | Asakura, Atsushi, Japan Society for the Promotion of Science KAKENHI, Ministry of Education, Culture, Sports, Science and Technology Supported Program for the Strategic Research Foundation at Private Universities |
| المصدر: | PLOS ONE ; volume 17, issue 2, page e0264171 ; ISSN 1932-6203 |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2022 |
| المجموعة: | PLOS Publications (via CrossRef) |
| الوصف: | We investigated whether time-of-day dependent changes in the rat soleus (SOL) muscle size, after eccentric exercises, operate via the mechanistic target of rapamycin (mTOR) signaling pathway. For our first experiment, we assigned 9-week-old male Wistar rats randomly into four groups: light phase (zeitgeber time; ZT6) non-trained control, dark phase (ZT18) non-trained control, light phase-trained, and dark phase-trained. Trained animals performed 90 min of downhill running once every 3 d for 8 weeks. The second experiment involved dividing 9-week-old male Wistar rats to control and exercise groups. The latter were subjected to 15 min of downhill running at ZT6 and ZT18. The absolute (+12.8%) and relative (+9.4%) SOL muscle weights were higher in the light phase-trained group. p70S6K phosphorylation ratio was 42.6% higher in the SOL muscle of rats that had exercised only in light (non-trained ZT6). Collectively, the degree of muscle hypertrophy in SOL is time-of-day dependent, perhaps via the mTOR/p70S6K signaling. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1371/journal.pone.0264171 |
| الاتاحة: | http://dx.doi.org/10.1371/journal.pone.0264171 https://dx.plos.org/10.1371/journal.pone.0264171 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.367618BE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0264171 |
|---|