التفاصيل البيبلوغرافية
العنوان: |
A randomized, double-blind comparison of tenofovir alafenamide versus tenofovir disoproxil fumarate, each coformulated with elvitegravir, cobicistat, and emtricitabine for initial HIV-1 treatment: Week 96 results |
المؤلفون: |
Wohl, David, Cheret, Antoine, Brunetta, Jason, Mussini, Cristina, Tebas, Pablo, Sax, Paul Edward Dward P.E., Cheng, Andrew K, Zhong, Lijie, Callebaut, Christian, Das, Moupali, Fordyce, Marshall, Oka, Shinichi, Friborg, Sandra, Villamejor, Kathleen, Huang, Jay, Guo, Susan, Liu, Hui, Wang, Hui, Miller, Michael, Margot, Nicolas, Clumeck, Nathan, Clarke, Amanda, Brinson, Cynthia, Stephens, Jeffrey, Tashima, Karen, Arribas, Jose, Rashbaum, Bruce |
المصدر: |
Journal of acquired immune deficiency syndromes, 72 (1 |
سنة النشر: |
2016 |
المجموعة: |
DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
مصطلحات موضوعية: |
Pharmacologie, Pathologie maladies infectieuses, Bone mineral density, HIV, Integrase inhibitor, Randomized controlled trial, Renal safety, Tenofovir alafenamide |
الوصف: |
In 2 double-blinded Phase 3 trials, 1733 antiretroviralnaive participants were randomized to tenofovir alafenamide (TAF), a tenofovir prodrug versus tenofovir disoproxil fumarate (TDF), each coformulated with elvitegravir/cobicistat/emtricitabine (E/C/F). At 96 weeks, 86.6% in the TAF arm and 85.2% in the TDF arm had HIV-1 RNA<50 c/mL [difference 1.5%; (95% CI: 21.8% to 4.8%)]. With TAF, there are smaller declines in bone mineral density and more favorable changes in proteinuria, albuminuria, and tubular proteinuria, and no cases of proximal tubulopathy compared with 2 for TDF. These longer-term data support E/C/F/TAF as a safe, welltolerated, and durable regimen for initial HIV-1 treatment. ; SCOPUS: ar.j ; info:eu-repo/semantics/published |
نوع الوثيقة: |
article in journal/newspaper |
وصف الملف: |
No full-text files |
اللغة: |
English |
Relation: |
uri/info:doi/10.1097/QAI.0000000000000940; uri/info:pmid/26829661; uri/info:scp/84973121361; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/236946 |
الاتاحة: |
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/236946 |
رقم الانضمام: |
edsbas.3674D583 |
قاعدة البيانات: |
BASE |