Academic Journal

A randomized, double-blind comparison of tenofovir alafenamide versus tenofovir disoproxil fumarate, each coformulated with elvitegravir, cobicistat, and emtricitabine for initial HIV-1 treatment: Week 96 results

التفاصيل البيبلوغرافية
العنوان: A randomized, double-blind comparison of tenofovir alafenamide versus tenofovir disoproxil fumarate, each coformulated with elvitegravir, cobicistat, and emtricitabine for initial HIV-1 treatment: Week 96 results
المؤلفون: Wohl, David, Cheret, Antoine, Brunetta, Jason, Mussini, Cristina, Tebas, Pablo, Sax, Paul Edward Dward P.E., Cheng, Andrew K, Zhong, Lijie, Callebaut, Christian, Das, Moupali, Fordyce, Marshall, Oka, Shinichi, Friborg, Sandra, Villamejor, Kathleen, Huang, Jay, Guo, Susan, Liu, Hui, Wang, Hui, Miller, Michael, Margot, Nicolas, Clumeck, Nathan, Clarke, Amanda, Brinson, Cynthia, Stephens, Jeffrey, Tashima, Karen, Arribas, Jose, Rashbaum, Bruce
المصدر: Journal of acquired immune deficiency syndromes, 72 (1
سنة النشر: 2016
المجموعة: DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB)
مصطلحات موضوعية: Pharmacologie, Pathologie maladies infectieuses, Bone mineral density, HIV, Integrase inhibitor, Randomized controlled trial, Renal safety, Tenofovir alafenamide
الوصف: In 2 double-blinded Phase 3 trials, 1733 antiretroviralnaive participants were randomized to tenofovir alafenamide (TAF), a tenofovir prodrug versus tenofovir disoproxil fumarate (TDF), each coformulated with elvitegravir/cobicistat/emtricitabine (E/C/F). At 96 weeks, 86.6% in the TAF arm and 85.2% in the TDF arm had HIV-1 RNA<50 c/mL [difference 1.5%; (95% CI: 21.8% to 4.8%)]. With TAF, there are smaller declines in bone mineral density and more favorable changes in proteinuria, albuminuria, and tubular proteinuria, and no cases of proximal tubulopathy compared with 2 for TDF. These longer-term data support E/C/F/TAF as a safe, welltolerated, and durable regimen for initial HIV-1 treatment. ; SCOPUS: ar.j ; info:eu-repo/semantics/published
نوع الوثيقة: article in journal/newspaper
وصف الملف: No full-text files
اللغة: English
Relation: uri/info:doi/10.1097/QAI.0000000000000940; uri/info:pmid/26829661; uri/info:scp/84973121361; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/236946
الاتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/236946
رقم الانضمام: edsbas.3674D583
قاعدة البيانات: BASE