التفاصيل البيبلوغرافية
| العنوان: |
Caralluma europaea (Guss.) N.E.Br.: Anti-Inflammatory, Antifungal, and Antibacterial Activities against Nosocomial Antibiotic-Resistant Microbes of Chemically Characterized Fractions |
| المؤلفون: |
Amrati, Fatima Ez-Zahra, Bourhia, Mohammed, Saghrouchni, Hamza, Slighoua, Meryem, Grafov, Andriy, Ullah, Riaz, Ezzeldin, Essam, Mostafa, Gamal A., Bari, Ahmed, Ibenmoussa, Samir, Bousta, Dalila |
| المساهمون: |
Department of Chemistry |
| بيانات النشر: |
MDPI |
| سنة النشر: |
2021 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
) N, Br, Caralluma europaea (Guss, anti-inflammatory, antibacterial, antifungal, chemical characterization, Chemical sciences |
| الوصف: |
Caralluma europaea (Guss.) N.E.Br.: (C. europaea) is a wild medicinal plant belonging to the family Apocynaceae. It is commonly used in traditional medicines for treating several diseases. The present work aims to evaluate the anti-inflammatory, antibacterial, and antifungal potentials of C. europaea fractions including hydro ethanol (ET CE), n-butanol (But CE), and polyphenol (Poly CE). The chemical composition of hydroethanol, n-butanol, and polyphenol-rich fractions from C. europaea were determined using GC-MS after silylation. The anti-inflammatory effect of hydroethanol, n-butanol, and polyphenol-rich fractions was studied by carrageenan-induced paw edema. Antibacterial and antifungal activities of hydroethanol, n-butanol, and polyphenol-rich fractions against Gram-positive bacteria, Gram-negative bacteria, and yeasts were assessed using the disc diffusion and micro-dilution assays. The findings of the chemical characterization affirmed the presence of interesting bioactive compounds in C. europaea fractions. The polyphenol-rich fraction was the best inhibitor of edema by75.68% after 6 h of treatment. The hydroethanol fraction was the most active against both bacteria and yeasts. This study contributes to society as it provides potential bioactive compounds in C. europaea extract, which may help in fighting nosocomial antibiotic-resistant microbes. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Funding: This work was funded by Deanship of Scientific Research at King Saud University through research group no (RG-1440-100). The research was also supported by European project Horizon 2020 MSCA-RISE2016-734759-VAHVISTUS. Acknowledgments: The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding this work through research group no (RG-1440-100). The authors are also grateful for the support of the European project Horizon 2020 MSCA-RISE-2016-734759-VAHVISTUS.; Amrati , F E-Z , Bourhia , M , Saghrouchni , H , Slighoua , M , Grafov , A , Ullah , R , Ezzeldin , E , Mostafa , G A , Bari , A , Ibenmoussa , S & Bousta , D 2021 , ' Caralluma europaea (Guss.) N.E.Br.: Anti-Inflammatory, Antifungal, and Antibacterial Activities against Nosocomial Antibiotic-Resistant Microbes of Chemically Characterized Fractions ' , Molecules , vol. 26 , no. 3 , 636 , pp. 1-13 . https://doi.org/10.3390/molecules26030636; ORCID: /0000-0002-7387-3676/work/99763025; http://hdl.handle.net/10138/326942; 0d066694-dbfa-43e0-9fbb-047fa30fc275; 000615455200001 |
| الاتاحة: |
http://hdl.handle.net/10138/326942 |
| Rights: |
cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.36644C18 |
| قاعدة البيانات: |
BASE |