Academic Journal
CD4 + T Cells Are Not Essential for Control of Early Acute Cryptosporidium parvum Infection in Neonatal Mice
| العنوان: | CD4 + T Cells Are Not Essential for Control of Early Acute Cryptosporidium parvum Infection in Neonatal Mice |
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| المؤلفون: | Korbel, Daniel S., Barakat, Farah M., Di Santo, James P., McDonald, Vincent |
| المساهمون: | Urban, J. F. |
| المصدر: | Infection and Immunity ; volume 79, issue 4, page 1647-1653 ; ISSN 0019-9567 1098-5522 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2011 |
| الوصف: | Cryptosporidiosis is an important diarrheal disease of humans and neonatal livestock caused by Cryptosporidium spp. that infect epithelial cells. Recovery from Cryptosporidium parvum infection in adult hosts involves CD4 + T cells with a strong Th1 component, but mechanisms of immunity in neonates are not well characterized. In the present investigation with newborn mice, similar acute patterns of infection were obtained in C57BL/6 wild-type (WT) and T and B cell-deficient Rag2 −/− mice. In comparison with uninfected controls, the proportion of intestinal CD4 + or CD8 + T cells did not increase in infected WT mice during recovery from infection. Furthermore, infection in neonatal WT mice depleted of CD4 + T cells was not exacerbated. Ten weeks after WT and Rag2 −/− mice had been infected as neonates, no patent infections could be detected. Treatment at this stage with the immunosuppressive drug dexamethasone produced patent infections in Rag2 −/− mice but not WT mice. Expression of inflammatory markers, including gamma interferon (IFN-γ) and interleukin-12p40 (IL-12p40), was higher in neonatal WT mice than in Rag2 −/− mice around the peak of infection, but IL-10 expression was also higher in WT mice. These results suggest that although CD4 + T cells may be important for elimination of C. parvum , these cells are dispensable for controlling the early acute phase of infection in neonates. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/iai.00922-10 |
| DOI: | 10.1128/IAI.00922-10 |
| الاتاحة: | http://dx.doi.org/10.1128/iai.00922-10 https://journals.asm.org/doi/pdf/10.1128/IAI.00922-10 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.364A3A35 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/iai.00922-10 |
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