Academic Journal
Reevaluation of sodium thiosulfate otoprotection using the consensus International Society of Paediatric Oncology Ototoxicity Scale: A report from the Children's Oncology Group study ACCL0431
| العنوان: | Reevaluation of sodium thiosulfate otoprotection using the consensus International Society of Paediatric Oncology Ototoxicity Scale: A report from the Children's Oncology Group study ACCL0431 |
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| المؤلفون: | Orgel, Etan, Knight, Kristin R., Villaluna, Doojduen, Krailo, Mark, Esbenshade, Adam J., Sung, Lillian, Freyer, David R. |
| المصدر: | Pediatric Blood & Cancer ; volume 70, issue 9 ; ISSN 1545-5009 1545-5017 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | In two randomized trials (Children's Oncology Group ACCL0431 and International Childhood Liver Tumour Strategy Group SIOPEL‐6), sodium thiosulfate (STS) demonstrated efficacy in preventing cisplatin‐induced hearing loss (CIHL). However, the measures used in those trials have been superseded by the consensus International Society of Paediatric Oncology (SIOP) Ototoxicity Scale. To provide benchmark data for STS efficacy when using this contemporary scale, we reanalyzed ACCL0431 hearing outcomes with the SIOP scale and using multiple timepoints. Compared to the control arm, STS significantly reduced CIHL when assessed by the SIOP scale across these different approaches. These results provide critical data to inform treatment discussions and support future potential trial designs comparing otoprotectants. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/pbc.30550 |
| الاتاحة: | http://dx.doi.org/10.1002/pbc.30550 https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.30550 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.3630143E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/pbc.30550 |
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