Academic Journal
Role of osteopontin in dendritic cell shaping of immune responses
| العنوان: | Role of osteopontin in dendritic cell shaping of immune responses |
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| المؤلفون: | Del Prete A., Scutera S., Sozzani S., Musso T. |
| المساهمون: | Del Prete A., Scutera S., Sozzani S., Musso T. |
| سنة النشر: | 2019 |
| المجموعة: | Università degli Studi di Brescia: OPENBS - Open Archive UniBS |
| مصطلحات موضوعية: | Autoimmune disease, Cancer, Dendritic cell, Mesenchymal stromal cell, Osteopontin, T cell polarization |
| الوصف: | Osteopontin (OPN) is a pleiotropic cytokine produced both by immune and non-immune cells and active on different cellular targets. OPN production has been associated with several pathological conditions, including autoimmune diseases (e.g. lupus, multiple sclerosis and rheumatoid arthritis) and cancer. Emerging evidence suggests that the role of OPN has been underestimated, as it seems to be working at multiple levels of immune regulation, such as the shaping of T cell effector responses, the regulation of the tumor microenvironment, and the functional interaction with mesenchymal stromal cells. In this context, dendritic cells (DCs) play a crucial role being both an important source and a cellular target for OPN action. DC family is composed by several cell subsets endowed with specific immune functions. OPN exerts its biological functions through multiple receptors and is produced in different intracellular and secreted forms. OPN production by DC subsets is emerging as a crucial mechanism of regulation in normal and pathological conditions and starts to be exploited as a therapeutic target. This review will focus on the role of DC-derived OPN in shaping immune response and on the complex role of this cytokines in the regulation in immune response. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31126876; info:eu-repo/semantics/altIdentifier/wos/WOS:000500920500003; journal:CYTOKINE & GROWTH FACTOR REVIEWS; http://hdl.handle.net/11379/517495; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85065837508; www.elsevier.com/inca/publications/store/8/6/8/index.htt |
| DOI: | 10.1016/j.cytogfr.2019.05.004 |
| الاتاحة: | http://hdl.handle.net/11379/517495 https://doi.org/10.1016/j.cytogfr.2019.05.004 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.361B6781 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cytogfr.2019.05.004 |
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