Academic Journal
Potential renoprotective effect of SGLT2 inhibitors against contrast-induced AKI in diabetic STEMI patients undergoing primary PCI
| العنوان: | Potential renoprotective effect of SGLT2 inhibitors against contrast-induced AKI in diabetic STEMI patients undergoing primary PCI |
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| المؤلفون: | Kültürsay, Barkın, Yılmaz, Cemalettin, Güven, Barış, Mutlu, Deniz, Karagöz, Ali |
| المصدر: | Polish Heart Journal (Kardiologia Polska); Vol 82, No 1 (2024); 29-36 |
| بيانات النشر: | Polish Cardiac Society |
| سنة النشر: | 2024 |
| المجموعة: | Via Medica Journals |
| مصطلحات موضوعية: | acute kidney injury, diabetes mellitus, primary percutaneous coronary intervention, renoprotection, SGLT2 inhibitor |
| الوصف: | Background: It has been demonstrated that there is a significant reduction in the incidence of cardiovascular events, mortality rates, and worsening kidney disease in patients using sodium-glucose cotransporter 2 inhibitors (SGLT2i). However, there is limited information about the effect of SGLT2i on the incidence of contrast-induced acute kidney injury (CI-AKI) in patients undergoing primary percutaneous intervention (pPCI). Aims: Our research was focused on examining how SGLT2i exposure impacts CI-AKI occurrence in patients with ST-segment elevation myocardial infarction (STEMI) and undergoing pPCI. Results: This retrospective, single-center, case-control study included diabetic patients diagnosed with STEMI who underwent pPCI in a tertiary healthcare center between 2021 and 2022. The study population included SGLT2i users (n = 130) and non-SGLT2i users (n = 165). Inverse probability propensity score weighting and doubly robust estimation were performed to decrease bias and to balance covariate distribution for estimating average treatment for those treated. In a doubly robust inverse probability weighted regression model, in which covariates were balanced, CI-AKI risk was also found to be lower in the SGLT2i-user group (OR: 0.86 [0.76–0.98]; 95% CI; P = 0.028). In addition, ejection fraction, admission creatinine, albumin, and volume of contrast media were found to be independent predictors of CI-AKI in patients presenting with STEMI and undergoing pPCI. Conclusion: Our study provides evidence supporting the potential protective effect of SGLT2i against CI-AKI in diabetic patients presenting with STEMI and undergoing pPCI. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; text/html |
| اللغة: | English |
| Relation: | https://journals.viamedica.pl/polish_heart_journal/article/view/98260 |
| DOI: | 10.33963/v.kp.98260 |
| الاتاحة: | https://journals.viamedica.pl/polish_heart_journal/article/view/98260 https://doi.org/10.33963/v.kp.98260 |
| Rights: | Przesyłając manuskrypt wraz z ilustracjami i tabelami, automatycznie i nieodpłatnie przenosi (przenoszą) na Polskie Towarzystwo Kardiologiczne wszelkie prawa autorskie do wydawania oraz rozpowszechniania nadesłanych materiałów we wszystkich znanych formach i na wszystkich znanych polach eksploatacji, bez ograniczeń terytorialnych językowych pod warunkiem, że materiały te zostaną zaakceptowane do publikacji. ; The copyright to the submitted manuscript is held by the Author, who grants the Polish Cardiac Society a nonexclusive licence to use, reproduce, and distribute the work, including for commercial purposes. Polish Heart Journal (Kardiologia Polska) is an open access journal that applies the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (CC BY-NC-ND 4.0), allowing third parties to download articles and share them with others, provided the original work is properly cited, not changed in any way, distributed under the same licence, and used for non-commercial purposes only. For commercial use, please contact the journal office: polishheartjournal@ptkardio.pl. If submitted work has been funded by institutional grant, the applicant may optionally choose to release the work under Creative Commons licence: attribution (CC BY) to meet the requirements of funding party, if applicable. Licence Terms can be downloaded here. |
| رقم الانضمام: | edsbas.35FDF74C |
| قاعدة البيانات: | BASE |
| DOI: | 10.33963/v.kp.98260 |
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