Academic Journal
Improved survival of autologous stem cell transplantation in primary refractory and relapsed Hodgkin lymphoma in the brentuximab vedotin era - real-world data from Hungary
| العنوان: | Improved survival of autologous stem cell transplantation in primary refractory and relapsed Hodgkin lymphoma in the brentuximab vedotin era - real-world data from Hungary |
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| المؤلفون: | Husi Kata, Szabó Roxána, Pinczés László Imre, Földeák Dóra Melinda, Dudley Réka, Szomor Árpád, Koller Beáta, Gopcsa László, Illés Árpád, Miltényi Zsófia |
| سنة النشر: | 2023 |
| المجموعة: | University of Szeged: SZTE Repository of Publications / SZTE Publicatio Repozitórium |
| مصطلحات موضوعية: | 03.02. Klinikai orvostan |
| الوصف: | Autologous stem cell transplantation (ASCT) is the standard treatment of primary refractory or relapsed Hodgkin-lymphoma, which can provide a cure rate of about 50%. The aim of our study was to analyze the data of 126 HL patients undergoing AHSCT in Hungary between 01/01/2016 and 31/12/2020. We assessed the progression-free and overall survival, the prognostic role of PET/CT performed before transplantation and effect of brentuximab vedotin (BV) treatment on survival outcomes. The median follow-up time from AHSCT was 39 (1-76) months. The 5-year OS comparing PET- and PET + patients was 90% v. 74% (p = 0.039), and 5-year PFS was 74% v. 40% (p = 0.001). There was no difference in either OS or PFS compared to those who did not receive BV before AHSCT. We compared BV treatments based on their indication (BV only after AHSCT as maintenance therapy, BV before and after AHSCT as maintenance treatment, BV only before AHSCT, no BV treatment). There was statistically significant difference in the 5-year PFS based on the inication of BV therapy. Recovery rates of our R/R HL patient population, who underwent AHSCT, improved significantly. Our positive results can be attributed to the PET/CT directed, response-adapted treatment approach, and the widespread use of BV. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | http://publicatio.bibl.u-szeged.hu/28123/1/Foldeak.pdf; Husi Kata; Szabó Roxána; Pinczés László Imre; Földeák Dóra Melinda; Dudley Réka; Szomor Árpád; Koller Beáta; Gopcsa László; Illés Árpád; Miltényi Zsófia: Improved survival of autologous stem cell transplantation in primary refractory and relapsed Hodgkin lymphoma in the brentuximab vedotin era - real-world data from Hungary. ANNALS OF HEMATOLOGY, 102 (9). pp. 2555-2563. ISSN 0939-5555 (2023) |
| DOI: | 10.1007/s00277-023-05354-8 |
| الاتاحة: | http://publicatio.bibl.u-szeged.hu/28123/ http://publicatio.bibl.u-szeged.hu/28123/1/Foldeak.pdf https://doi.org/10.1007/s00277-023-05354-8 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.35ED13D7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00277-023-05354-8 |
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