التفاصيل البيبلوغرافية
| العنوان: |
Radiation-induced accelerated aging of the brain vasculature in young adult survivors of childhood brain tumors |
| المؤلفون: |
Remes, Tiina Maria, Suo-Palosaari, Maria Helena, Koskenkorva, Päivi K. T., Sutela, Anna K., Toiviainen-Salo, Sanna-Maria, Arikoski, Pekka M., Arola, Mikko O., Heikkilä, Vesa-Pekka, Kapanen, Mika, Lähteenmäki, Päivi Maria, Lönnqvist, Tuula R. I., Niiniviita, Hannele, Pokka, Tytti M-L, Porra, Liisa, Riikonen, V. Pekka, Seppälä, Jan, Sirkiä, Kirsti H., Vanhanen, Antti, Rantala, Heikki M. J., Harila-Saari, Arja H., Ojaniemi, Marja K. |
| المساهمون: |
HUS Medical Imaging Center, Department of Diagnostics and Therapeutics, University of Helsinki, Helsinki University Hospital Area, HUS Children and Adolescents, Clinicum, Lastentautien yksikkö, Children's Hospital, Department of Physics, HUS Comprehensive Cancer Center, Department of Oncology |
| بيانات النشر: |
Oxford University Press |
| سنة النشر: |
2021 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
brain tumor, cerebrovascular disease, radiotherapy, stroke, survivor, CEREBRAL WHITE-MATTER, SMALL-VESSEL DISEASE, HEALTH-CARE PROFESSIONALS, RISK-FACTORS, ISCHEMIC-STROKE, CHOLESTEROL LEVELS, BLOOD-PRESSURE, MICROBLEEDS, ASSOCIATION, Neurosciences, Neurology and psychiatry, Cancers |
| الوصف: |
Background. Cranial radiotherapy may damage the cerebral vasculature. The aim of this study was to understand the prevalence and risk factors of cerebrovascular disease (CVD) and white matter hyperintensities (WMHs) in childhood brain tumors (CBT) survivors treated with radiotherapy. Methods. Seventy CBT survivors who received radiotherapy were enrolled in a cross-sectional study at a median 20 years after radiotherapy cessation. The prevalence of and risk factors for CVD were investigated using MRI, MRA, and laboratory testing. Tumors, their treatment, and stroke-related data were retrieved from patients' files. Results. Forty-four individuals (63%) had CVD at a median age of 27 years (range, 16-43 years). The prevalence rates at 20 years for CVD, small-vessel disease, and large-vessel disease were 52%, 38%, and 16%, respectively. Ischemic infarcts were diagnosed in 6 survivors, and cerebral hemorrhage in 2. Lacunar infarcts were present in 7, periventricular or deep WMHs in 34 (49%), and mineralizing microangiopathy in 21 (30%) survivors. Multiple pathologies were detected in 44% of the participants, and most lesions were located in a high-dose radiation area. Higher blood pressure was associated with CVD and a presence of WMHs. Higher cholesterol levels increased the risk of ischemic infarcts and WMHs, and lower levels of high-density lipoprotein and higher waist circumference increased the risk of lacunar infarcts. Conclusions. Treating CBTs with radiotherapy increases the risk of early CVD and WMHs in young adult survivors. These results suggest an urgent need for investigating CVD prevention in CBT patients. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
This work was supported by Special State Grants for Health Research in the Department of Pediatrics and Adolescence, Oulu University Hospital, Finland, the Vare Foundation for Pediatric Cancer Research, Finland, the Foundation of Paivikki and Sakari Sohlberg, Finland, the Foundation of Arvo and Lea Ylppo, Finland, the Foundation for Pediatric Research, Finland, the Foundation of Emil Aaltonen, Finland, the Foundation of Thelma Makikyro, Finland, the Cancer Foundation of Northern Finland, the Foundation of Alma and K. A. Snellman, Finland, and the Foundation of Marta Donner, Finland (to T.R.), and the Cancer Society of Finland (to H.R., A.H.-S., and M.O.).; Remes , T M , Suo-Palosaari , M H , Koskenkorva , P K T , Sutela , A K , Toiviainen-Salo , S-M , Arikoski , P M , Arola , M O , Heikkilä , V-P , Kapanen , M , Lähteenmäki , P M , Lönnqvist , T R I , Niiniviita , H , Pokka , T M-L , Porra , L , Riikonen , V P , Seppälä , J , Sirkiä , K H , Vanhanen , A , Rantala , H M J , Harila-Saari , A H & Ojaniemi , M K 2020 , ' Radiation-induced accelerated aging of the brain vasculature in young adult survivors of childhood brain tumors ' , Neuro-Oncology practice , vol. 7 , no. 4 , pp. 415-427 . https://doi.org/10.1093/nop/npaa002; ORCID: /0000-0003-3639-944X/work/86483404; http://hdl.handle.net/10138/331486; 6c128001-d8a5-49b7-b2cf-d498ac1cbb38; 000593119700009 |
| الاتاحة: |
http://hdl.handle.net/10138/331486 |
| Rights: |
cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.35D34557 |
| قاعدة البيانات: |
BASE |