Academic Journal
Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans
| العنوان: | Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans |
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| المؤلفون: | Liu, Kui, Li, Quan Zhen, Delgado Vega, Angelica M., Abelson, Anna Karin, Sánchez, Elena, Kelly, Jennifer A., Li, Li, Liu, Yang, Zhou, Jinchun, Yan, Mei, Ye, Qiu, Liu, Shenxi, Xie, Chun, Zhou, Xin J., Chung, Sharon A., Pons Estel, Bernardo, Witte, Torsten, De Ramón, Enrique, Bae, Sang Cheol, Barizzone, Nadia, Sebastiani, Gian Domenico, Merrill, Joan T., Gregersen, Peter K., Gilkeson, Gary G., Kimberly, Robert P., Vyse, Timothy J., Kim, Il, D'Alfonso, Sandra, Martin, Javier, Harley, John B., Criswell, Lindsey A., Wakeland, Edward K, Alarcón Riquelme, Marta E., Mohan, Chandra, Danieli, Maria Giovanna, Querini, Patrizia Rovere, Migliaresi, Sergio, Scherbarth, Hugo R., Lopez, Jorge A., Motta, Estela L., Gamron, Susana, Drenkard, Cristina, Menso, Emilia, Allievi, Alberto, Tate, Guillermo A., Presas, José L., Palatnik, Simon A., Abdala, Marcelo, Bearzotti, Mariela, Alvarellos, Alejandro, Caeiro, Francisco, Bertoli, Ana, Paira, Sergio, Roverano, Susana, Graf, Cesar E., Bertero, Estela, Caprarulo, Cesar, Buchanan, Griselda, Guillerón, Carolina, Grimaudo, Sebastian, Manni, Jorge, Catoggio, Luis J., Soriano, Enrique R., Santos, Carlos D., Prigione, Cristina, Ramos, Fernando A., Navarro, Sandra M., Berbotto, Guillermo A., Jorfen, Marisa, Romero, Elisa J., Garcia, Mercedes A., Marcos, Juan C., Marcos, Ana I., Perandones, Carlos E., Eimon, Alicia, Battagliotti, Cristina G., Armadi Simab, K., Gross, Wolfgang L., Gromnica Ihle, Erika, Peter, Hans Hartmut, Manger, Karin, Schnarr, Sebastian, Zeidler, Henning, Schmidt, Reinhold E., Ortego, Norberto, Callejas, José L., Jiménez Alonso, Juan, Sabio, Mario, Sánchez Román, Julio, Garcia Hernandez, Francisco J., Camps, Mayte, López Nevot, Miguel Angel, González Escribano, Maria F., Langefeld, Carl, Tsao, Betty, Jacob, Chaim, GALEAZZI, MAURO |
| المساهمون: | Liu, Kui, Li, Quan Zhen, Delgado Vega, Angelica M., Abelson, Anna Karin, Sánchez, Elena, Kelly, Jennifer A., Li, Li, Liu, Yang, Zhou, Jinchun, Yan, Mei, Ye, Qiu, Liu, Shenxi, Xie, Chun, Zhou, Xin J., Chung, Sharon A., Pons Estel, Bernardo, Witte, Torsten, De Ramón, Enrique, Bae, Sang Cheol, Barizzone, Nadia, Sebastiani, Gian Domenico, Merrill, Joan T., Gregersen, Peter K., Gilkeson, Gary G., Kimberly, Robert P., Vyse, Timothy J., Kim, Il, D'Alfonso, Sandra, Martin, Javier, Harley, John B., Criswell, Lindsey A., Wakeland, Edward K, Alarcón Riquelme, Marta E., Mohan, Chandra, Danieli, Maria Giovanna, Galeazzi, Mauro, Querini, Patrizia Rovere, Migliaresi, Sergio, Scherbarth, Hugo R., Lopez, Jorge A., Motta, Estela L., Gamron, Susana, Drenkard, Cristina, Menso, Emilia, Allievi, Alberto, Tate, Guillermo A., Presas, José L., Palatnik, Simon A., Abdala, Marcelo, Bearzotti, Mariela, Alvarellos, Alejandro, Caeiro, Francisco, Bertoli, Ana, Paira, Sergio, Roverano, Susana, Graf, Cesar E., Bertero, Estela, Caprarulo, Cesar, Buchanan, Griselda, Guillerón, Carolina, Grimaudo, Sebastian, Manni, Jorge, Catoggio, Luis J., Soriano, Enrique R., Santos, Carlos D., Prigione, Cristina, Ramos, Fernando A., Navarro, Sandra M., Berbotto, Guillermo A., Jorfen, Marisa, Romero, Elisa J., Garcia, Mercedes A., Marcos, Juan C., Marcos, Ana I., Perandones, Carlos E., Eimon, Alicia, Battagliotti, Cristina G., Armadi Simab, K., Gross, Wolfgang L., Gromnica Ihle, Erika, Peter, Hans Hartmut, Manger, Karin, Schnarr, Sebastian, Zeidler, Henning, Schmidt, Reinhold E., Ortego, Norberto, Callejas, José L., Jiménez Alonso, Juan, Sabio, Mario, Sánchez Román, Julio, Garcia Hernandez, Francisco J., Camps, Mayte, López Nevot, Miguel Angel, González Escribano, Maria F., Langefeld, Carl, Tsao, Betty, Jacob, Chaim |
| سنة النشر: | 2009 |
| المجموعة: | Università degli Studi di Siena: USiena air |
| مصطلحات موضوعية: | Animal, Base Sequence, DNA, Disease Models, Female, Gene Expression Profiling, Glomerular Basement Membrane, Human, Kallikrein, Lupus Erythematosus, Systemic, Lupus Nephriti, Mice, Inbred BALB C, Inbred DBA, Molecular Sequence Data, Oligonucleotide Array Sequence Analysi, Polymorphism, Genetic, Sequence Homology, Nucleic Acid, Species Specificity, Medicine (all) |
| الوصف: | Immune-mediated nephritis contributes to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous lupus nephritis. Inbred mouse strains differ in susceptibility to anti-GBM antibody-induced and spontaneous lupus nephritis. This study sought to clarify the genetic and molecular factors that may be responsible for enhanced immune-mediated renal disease in these models. When the kidneys of 3 mouse strains sensitive to anti-GBM antibody-induced nephritis were compared with those of 2 control strains using microarray analysis, one-fifth of the underexpressed genes belonged to the kallikrein gene family, which encodes serine esterases. Mouse strains that upregulated renal and urinary kallikreins exhibited less evidence of disease. Antagonizing the kallikrein pathway augmented disease, while agonists dampened the severity of anti-GBM antibody-induced nephritis. In addition, nephritis-sensitive mouse strains had kallikrein haplotypes that were distinct from those of control strains, including several regulatory polymorphisms, some of which were associated with functional consequences. Indeed, increased susceptibility to anti-GBM antibody-induced nephritis and spontaneous lupus nephritis was achieved by breeding mice with a genetic interval harboring the kallikrein genes onto a disease-resistant background. Finally, both human SLE and spontaneous lupus nephritis were found to be associated with kallikrein genes, particularly KLK1 and the KLK3 promoter, when DNA SNPs from independent cohorts of SLE patients and controls were compared. Collectively, these studies suggest that kallikreins are protective disease-associated genes in anti-GBM antibody-induced nephritis and lupus. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/19307730; info:eu-repo/semantics/altIdentifier/wos/WOS:000264830100028; volume:119; issue:4; firstpage:911; lastpage:923; numberofpages:13; journal:THE JOURNAL OF CLINICAL INVESTIGATION; http://hdl.handle.net/11365/996506; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-65249086734; http://www.jci.org/articles/view/36728/pdf |
| DOI: | 10.1172/JCI36728 |
| الاتاحة: | http://hdl.handle.net/11365/996506 https://doi.org/10.1172/JCI36728 http://www.jci.org/articles/view/36728/pdf |
| رقم الانضمام: | edsbas.35B33F42 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1172/JCI36728 |
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