Academic Journal
Generating high-resolution synthetic CT from lung MRI with ultrashort echo-times: initial evaluation in cystic fibrosis
| العنوان: | Generating high-resolution synthetic CT from lung MRI with ultrashort echo-times: initial evaluation in cystic fibrosis |
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| المؤلفون: | Longuefosse, Arthur, Raoult, Julien, Benlala, Ilyes, Denis de Senneville, Baudouin, Benkert, Thomas, Macey, Julie, Bui, Stéphanie, Berger, Patrick, Ferretti, Gilbert, Gaubert, Jean-Yves, Liberge, Renan, Hutt, Antoine, Morel, Baptiste, Laurent, François, Baldacci, Fabien, Dournes, Gaël |
| المساهمون: | Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche Cardio-Thoracique de Bordeaux Bordeaux (CRCTB), Université Bordeaux Segalen - Bordeaux 2-Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Modélisation Mathématique pour l'Oncologie (MONC), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Institut Bergonié Bordeaux, UNICANCER-UNICANCER-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), ANR-10-IDEX-0003,IDEX BORDEAUX,Initiative d'excellence de l'Université de Bordeaux(2010), ANR-16-IDEX-0003,FUTURE,FUTURE(2016) |
| المصدر: | ISSN: 0033-8419. |
| بيانات النشر: | HAL CCSD Radiological Society of North America |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | CF, cystic fibrosis UTE-MRI, ultrashort echo time MRI PFT, pulmonary function test GAN, generalized adversarial networks ICC, intraclass correlation coefficient, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs] |
| الوصف: | International audience ; Background: Lung MRI with ultrashort echo times (UTE-MRI) enables high-resolution and radiation-free morphological imaging, however, its imaging quality is still lower than CT. Purpose: To assess the image quality and clinical applicability of synthetic CTs generated from lung UTE-MRI using Generative Adversarial Networks (GAN).Methods and Materials: This retrospective study included patients with Cystic Fibrosis (CF) who underwent both UTE-MRI and CT on the same day at six institutions between January 2018 and December 2022. The 2D GAN algorithm was trained using paired MR-to-CT slices and tested, along with an external dataset. Imaging quality was assessed quantitatively by measuring apparent contrast-to-noise-ratio, apparent signal-to-noise-ratio, and overall noise and qualitatively using visual scores for features including artifacts. Two readers evaluated CF-related structural abnormalities and used them to determine clinical Bhalla scores.Results: The training, test, and external datasets were comprised of 82 CF patients (mean age, 21 ± 11 [SD]; 42 males), 28 patients (mean age, 18 ± 11; 16 males), and 46 patients (mean age, 20 ± 11; 24 males), respectively. In the test dataset, the contrast-to-noise ratio of synthetic CTs (median, 303 [interquartile range: 221, 382]) was higher than that of UTE-MRI (9.3 [6.6, 35]; P < .001). The median signal-to-noise ratio was similar between the synthetic and corresponding CT (88 [84, 92] vs 88 [86, 91]; P = 0.96). Synthetic CT had a lower noise level than CT (median score, 22 [18, 30] vs 42 [32, 50]; P < .001) and the lowest level of artifacts (median score, 0 [0, 0]; P ≤ .001). The concordance between Bhalla scores for synthetic and real CTs was almost perfect (ICC, ≥ 0.92). Conclusion: Synthetic CTs showed almost perfect concordance with CTs for the depiction of Cystic Fibrosis-related pulmonary alterations and had better image quality than lung MRI with ultrashort echo-times. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1148/radiol.230052 |
| الاتاحة: | https://hal.science/hal-04268631 https://hal.science/hal-04268631v1/document https://hal.science/hal-04268631v1/file/2023_Radiology_MR_to_CT_GAN.pdf https://doi.org/10.1148/radiol.230052 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.35A7A0BD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1148/radiol.230052 |
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