Academic Journal
Electrospray Delivery of Insulin Lowers Blood Glucose in Rats
| العنوان: | Electrospray Delivery of Insulin Lowers Blood Glucose in Rats |
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| المؤلفون: | Koike, Kanako, Ikemoto, Kazuto, Sakai, Takafumi |
| المصدر: | Chemistry Letters ; volume 44, issue 10, page 1295-1297 ; ISSN 0366-7022 1348-0715 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | General Chemistry |
| الوصف: | Most peptide or protein-based drugs like insulin require an injection for delivery. Alternatives routes of delivery could potentially improve treatment efficacy and clearly improve the patient’s quality of life. Herein, we evaluated an electrospray delivery method for dosing insulin in rats. We found that an electrospray formulation of insulin in aqueous deoxycholic acid (DCA) was effective at transporting insulin into the bloodstream of rats and thereby lowering blood glucose. Our analysis indicated that the inclusion of DCA likely enables insulin uptake both by decreasing the particle size of electrosprayed droplets and by dissolving a layer of mucosal cells. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1246/cl.150469 |
| الاتاحة: | http://dx.doi.org/10.1246/cl.150469 https://academic.oup.com/chemlett/article-pdf/44/10/1295/55639055/cl.150469.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.359415B4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1246/cl.150469 |
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