Academic Journal
Relapsing Neuromyelitis Optica: demographic and clinical features in Iranian patients
| العنوان: | Relapsing Neuromyelitis Optica: demographic and clinical features in Iranian patients |
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| المؤلفون: | Sahraian, M. A., Moinfar, Z., Khorramnia, S., Mohammad Ebrahim, M. |
| المصدر: | European Journal of Neurology ; volume 17, issue 6, page 794-799 ; ISSN 1351-5101 1468-1331 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2010 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background: Neuromyelitis Optica (NMO) is a severe inflammatory demyelinating disease of the central nervous system with distinguishing features from multiple sclerosis (MS). NMO has an unknown etiology with poor prognosis in which anti‐aquaporin‐4 receptor IgG seems to play a major role. The purpose of this study is to represent a clinical and demographic data of NMO in Iranian population. Methods: Of 1800 patients attending our MS clinic, 44 patients with NMO were recruited from 2006 to 2009. Results: Female to male ratio was 3:1 and the disease affected women in younger ages than men ( P = 0.04). The median expanded disability status scale score was 3 and the mean duration of symptoms was 4.53 ± 3.41 (median = 4) years with annual relapse rate of 1.13 year/patient. The most frequent symptoms at presentation were optic neuritis 22 (50%) and transverse myelitis 14 (31.8%). Out of 12 patients whose titer of NMO‐IgG was measured, four (30.7%) patients were seropositive. Twenty‐eight patients (63%) received azathioprine for a mean duration of 16.84 ± 27.91 months with significantly lower annual relapse rate (0.4 year/patient). Conclusions: Iranian patients as a Caucasian population living in Asia seem to have the same clinical features in comparison with the reported studies from Western countries. Although the duration of follow‐up was not too long, but they may possibly have a more benign course. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1468-1331.2009.02928.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1468-1331.2009.02928.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1468-1331.2009.02928.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1468-1331.2009.02928.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.357FD5E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1468-1331.2009.02928.x |
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