Academic Journal
A patient with a 20-year lag phase between JAK2-V617F+ myeloproliferation and NPM1-mutated AML arguing against a common origin of disease
| العنوان: | A patient with a 20-year lag phase between JAK2-V617F+ myeloproliferation and NPM1-mutated AML arguing against a common origin of disease |
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| المؤلفون: | Roug, Anne Stidsholt, Nyvold, Charlotte Guldborg, Juhl-Christensen, Caroline, Christensen, Mariann, Schnittger, Susanne, Hokland, Peter |
| المصدر: | Roug , A S , Nyvold , C G , Juhl-Christensen , C , Christensen , M , Schnittger , S & Hokland , P 2011 , ' A patient with a 20-year lag phase between JAK2-V617F+ myeloproliferation and NPM1-mutated AML arguing against a common origin of disease ' , European Journal of Haematology , vol. 87 , no. 5 , pp. 461-463 . https://doi.org/10.1111/j.1600-0609.2011.01669.x |
| سنة النشر: | 2011 |
| المجموعة: | Aarhus University: Research |
| الوصف: | We have sought to unravel the molecular biology of a female patient who in 1985 at the age of 55 was diagnosed with a chronic myeloproliferative neoplasm (MPN) and in whom overt acute myeloid leukemia (AML) developed in 2005. To this end, DNA and RNA (extracted from either paraffin-embedded bone marrow (BM) or from BM and/or peripheral blood stored in an RNA/DNA-preserving buffer) were analyzed by qPCR and by capillary gel electrophoresis of PCR products. We found the patient to be JAK2-V617F mutation positive throughout the course of disease, while a mutation of the nucleophosmin (NPM1) gene emerged at AML diagnosis and relapse. The 20-yr lag phase between the polycythemia vera and the AML adds indirect evidence to the growing realization that the leukemic transformation in patients with MPN occurs from in a JAK2 wild-type stem cell. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1600-0609.2011.01669.x |
| الاتاحة: | https://pure.au.dk/portal/da/publications/a-patient-with-a-20year-lag-phase-between-jak2v617f-myeloproliferation-and-npm1mutated-aml-arguing-against-a-common-origin-of-disease(5b97dfd6-f95f-405b-8398-749e192190eb).html https://doi.org/10.1111/j.1600-0609.2011.01669.x |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.356C4D5C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1600-0609.2011.01669.x |
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