Academic Journal
Lower semantic fluency scores and a phonemic-over-semantic advantage predict abnormal CSF P-tau181 levels in Aβ + patients within the Alzheimer’s disease clinical spectrum
| العنوان: | Lower semantic fluency scores and a phonemic-over-semantic advantage predict abnormal CSF P-tau181 levels in Aβ + patients within the Alzheimer’s disease clinical spectrum |
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| المؤلفون: | Aiello E. N., Verde F., Solca F., Milone I., Giacopuzzi Grigoli E., Dubini A., Ratti A., Ferrucci R., Torresani E., Priori A., Ticozzi N., Silani V., Poletti B. |
| المساهمون: | Aiello, E, Verde, F, Solca, F, Milone, I, Giacopuzzi Grigoli, E, Dubini, A, Ratti, A, Ferrucci, R, Torresani, E, Priori, A, Ticozzi, N, Silani, V, Poletti, B |
| بيانات النشر: | Springer-Verlag Italia s.r.l. IT |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| مصطلحات موضوعية: | Alzheimer’s disease, Cerebrospinal fluid, Mild cognitive impairment, Semantic, Tau, Verbal fluency |
| الوصف: | Background: The present study aimed to determine whether patients with mild cognitive impairment (MCI) and dementia due to Alzheimer’s disease (AD), semantic verbal fluency (SVF), and the semantic-phonemic discrepancy (SPD) could predict abnormal cerebrospinal fluid (CSF) phosphorylated tau (P-tau181) and total tau (T-tau) levels. Methods: Phonemic verbal fluency (PVF) and SVF scores of N = 116 Aβ-positive patients with either MCI due to AD (N = 39) or probable AD dementia (ADD; N = 77) were retrospectively collected. The SPD was computed by subtracting PVF scores from SVF ones (positive and negative values corresponding to a semantic and phonemic advantage, respectively). Patients were cognitively phenotyped via a thorough test battery and profiled according to the amyloidosis/tauopathy/neurodegeneration (ATN) framework via CSF analyses. Two separate sets of logistic regressions were run to predict normal vs. abnormal P-tau181 and T-tau levels by encompassing as predictors SVF + PVF and SPD and covarying for demographic, disease-related features, and cognitive profile. Results: Lower SVF, but not PVF, scores, as well as a greater phonemic advantage (i.e., negative SPD values), predicted abnormal CSF P-tau181 levels (p ≤.01). Moreover, lower SVF scores were selectively predictive of abnormal CSF T-tau levels too (p =.016), while the SPD was not. Discussion: SVF and the SPD are able to predict tauopathy across the AD spectrum, thus supporting their status of valid, and sufficiently specific, cognitive markers of AD. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36705785; info:eu-repo/semantics/altIdentifier/wos/WOS:000923111400002; volume:44; issue:6; firstpage:1979; lastpage:1985; numberofpages:7; journal:NEUROLOGICAL SCIENCES; https://hdl.handle.net/10281/520739 |
| DOI: | 10.1007/s10072-023-06643-w |
| الاتاحة: | https://hdl.handle.net/10281/520739 https://doi.org/10.1007/s10072-023-06643-w |
| رقم الانضمام: | edsbas.3569ADCE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10072-023-06643-w |
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