Academic Journal
Global impact of somatic structural variation on the cancer proteome
| العنوان: | Global impact of somatic structural variation on the cancer proteome |
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| المؤلفون: | Fengju Chen, Yiqun Zhang, Darshan S. Chandrashekar, Sooryanarayana Varambally, Chad J. Creighton |
| المصدر: | Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023) |
| بيانات النشر: | Nature Portfolio |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Science |
| الوصف: | Both proteome and transcriptome data can help assess the relevance of non-coding somatic mutations in cancer. Here, we combine mass spectrometry-based proteomics data with whole genome sequencing data across 1307 human tumors spanning various tissues to determine the extent somatic structural variant (SV) breakpoint patterns impact protein expression of nearby genes. We find that about 25% of the hundreds of genes with SV-associated cis-regulatory alterations at the mRNA level are similarly associated at the protein level. SVs associated with enhancer hijacking, retrotransposon translocation, altered DNA methylation, or fusion transcripts are implicated in protein over-expression. SVs combined with altered protein levels considerably extend the numbers of patients with tumors somatically altered for critical pathways. We catalog both SV breakpoint patterns involving patient survival and genes with nearby SV breakpoints associated with increased cell dependency in cancer cell lines. Pan-cancer proteogenomics identifies targetable non-coding alterations, by virtue of the associated deregulated genes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-1723 |
| Relation: | https://doi.org/10.1038/s41467-023-41374-8; https://doaj.org/toc/2041-1723; https://doaj.org/article/4571271353214368aca9e8db32038159 |
| DOI: | 10.1038/s41467-023-41374-8 |
| الاتاحة: | https://doi.org/10.1038/s41467-023-41374-8 https://doaj.org/article/4571271353214368aca9e8db32038159 |
| رقم الانضمام: | edsbas.355A3F10 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-023-41374-8 |