Academic Journal
Prognostic Role of Right Ventricular Function in Patients With Heart Failure Undergoing Cardiac Resynchronization Therapy
| العنوان: | Prognostic Role of Right Ventricular Function in Patients With Heart Failure Undergoing Cardiac Resynchronization Therapy |
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| المؤلفون: | RAPACCIUOLO, ANTONIO, ESPOSITO, FRANCESCA GIOVANNA, AGRESTA, ALESSIA, Maffè, Stefano, Palmisano, Pietro, Ferraro, Anna, Cecchetto, Antonella, D'Onofrio, Antonio, Solimene, Francesco, Musatti, Paola, Paffoni, Paola, Parravicini, Umberto, Botto, Giovanni Luca, Malacrida, Maurizio, Stabile, Giuseppe |
| المساهمون: | Rapacciuolo, Antonio, Maffè, Stefano, Palmisano, Pietro, Ferraro, Anna, Cecchetto, Antonella, D'Onofrio, Antonio, Solimene, Francesco, Musatti, Paola, Paffoni, Paola, Esposito, FRANCESCA GIOVANNA, Parravicini, Umberto, Agresta, Alessia, Botto, Giovanni Luca, Malacrida, Maurizio, Stabile, Giuseppe |
| سنة النشر: | 2016 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | cardiac resynchronization therapy, heart failure, remodeling heart failure, right ventricular function |
| الوصف: | BACKGROUND: Because 20% to 40% of patients undergoing cardiac resynchronization therapy (CRT) do not respond to it, identification of potential factors predicting response is a relevant research topic. HYPOTHESIS: There is a possible association between right ventricular function and response to CRT. METHODS: We analyzed 227 patients from the Cardiac Resynchronization Therapy Modular Registry (CRT-MORE) who received CRT according to current guidelines from March to December 2013. Response to therapy was defined as a decrease of ≥15% in left ventricular end-systolic volume (LVESV) at 6 months. RESULTS: The tricuspid annular plane systolic excursion (TAPSE) value that best predicted improvement in LVESV (sensitivity 68%, specificity 54%) was 17 mm. Stratifying patients according to TAPSE, LVESV decreased ≥15% in 78% of patients with TAPSE >17 mm (vs 59% in patients with TAPSE ≤17 mm; P = 0.006). At multivariate analysis, TAPSE >17 mm was independently associated with LVESV improvement (odds ratio: 1.97, 95% confidence interval: 1.03-3.80, P < 0.05), together with ischemic etiology (odds ratio: 0.39, 95% confidence interval: 0.20-0.75, P < 0.01). These results were confirmed for New York Heart Association class III to IV patients (79% echocardiographic response rate in patients with TAPSE >17 mm vs 55% in patients with TAPSE <17 mm; P = 0.012). CONCLUSIONS: Baseline signs of right ventricular dysfunction suggest possible remodeling after CRT. A TAPSE value of 17 mm was identified as a good cutoff for predicting a better response to CRT in patients with both mildly symptomatic and severe heart failure. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000390605200004; volume:39; issue:11; firstpage:640; lastpage:645; numberofpages:6; journal:CLINICAL CARDIOLOGY; http://hdl.handle.net/11588/640014; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84979787986 |
| DOI: | 10.1002/clc.22574 |
| DOI: | 10.1002/clc.22574/full |
| الاتاحة: | http://hdl.handle.net/11588/640014 https://doi.org/10.1002/clc.22574 http://onlinelibrary.wiley.com/doi/10.1002/clc.22574/full |
| رقم الانضمام: | edsbas.3527DE15 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/clc.22574 |
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