Academic Journal
TLR3/TRIF and MAVS Signaling Is Essential in Regulating Mucosal T Cell Responses during Rotavirus Infection
| العنوان: | TLR3/TRIF and MAVS Signaling Is Essential in Regulating Mucosal T Cell Responses during Rotavirus Infection |
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| المؤلفون: | Zhang, Rong-Rong, Yang, Xue-Yao, Yang, Yong-Lei, Guo, Tian-Kui, Huang, Jing-Shu, Yang, Ying-Shi, Shi, Chun-Wei, Yang, Gui-Lian, Huang, Hai-Bin, Wang, Jian-Zhong, Jiang, Yan-Long, Cao, Xin, Wang, Nan, Zeng, Yan, Yang, Wen-Tao, Wang, Chun-Feng |
| المساهمون: | MOST | National Natural Science Foundation of China |
| المصدر: | The Journal of Immunology ; volume 213, issue 7, page 1008-1022 ; ISSN 0022-1767 1550-6606 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2024 |
| الوصف: | The functions of the natural dsRNA sensors TLR3 (TRIF) and RIG-I (MAVS) are crucial during viral challenge and have not been accurately clarified in adaptive immune responses to rotavirus (RV) infection. In this study, we found that RV infection caused severe pathological damage to the small intestine of TLR3−/− and TRIF−/− mice. Our data found that dendritic cells from TLR3−/− and TRIF−/− mice had impaired Ag presentation to the RV and attenuated initiation of T cells upon viral infection. These attenuated functions resulted in impaired CD4+ T and CD8+ T function in mice lacking TLR3-TRIF signaling postinfection. Additionally, attenuated proliferative capacity of T cells from TLR3−/− and TRIF−/− mice was observed. Subsequently, we observed a significant reduction in the absolute number of memory T cells in the spleen and mesenteric lymph node (MLN) of TRIF−/− recipient mice following RV infection in a bone marrow chimeric model. Furthermore, there was reduced migration of type 2 classical dendritic cells from the intestine to MLNs after RV infection in TLR3−/− and TRIF−/− mice. Notably, RV infection resulted in attenuated killing of spleen and MLN tissues in TRIF−/− and MAVS−/− mice. Finally, we demonstrated that RV infection promoted apoptosis of CD8+ T cells in TRIF−/− and TLR3−/−MAVS−/− mice. Taken together, our findings highlight an important mechanism of TLR3 signaling through TRIF in mucosal T cell responses to RV and lay the foundation for the development of a novel vaccine. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.4049/jimmunol.2300867 |
| الاتاحة: | https://doi.org/10.4049/jimmunol.2300867 https://academic.oup.com/jimmunol/article-pdf/213/7/1008/61539437/ji2300867.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.3524D928 |
| قاعدة البيانات: | BASE |
| DOI: | 10.4049/jimmunol.2300867 |
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