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Sex-related impact on clinical outcomes of patients treated with drug-eluting stents according to clinical presentation: Patient-level pooled analysis from the GRAND-DES registry

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العنوان: Sex-related impact on clinical outcomes of patients treated with drug-eluting stents according to clinical presentation: Patient-level pooled analysis from the GRAND-DES registry
المؤلفون: Shin, Eun-Seok, Jun, Eun Jung, Han, Jung-Kyu, Kong, Min Gyu, Kang, Jeehoon, Zheng, Chengbin, Garg, Scot, Choi, Young Jin, Bae, Jang-Whan, Chun, Kook-Jin, Kim, Doo-Il, Rha, Seung-Woon, Lee, Sung Yun, Rhew, Jay Young, Woo, Seong-Ill, Lee, Han Cheol, Jeong, Jin-Ok, Yang, Han-Mo, Park, Kyung Woo, Kang, Hyun Jae, Koo, Bon Kwon, Chae, In-Ho, Kim, Hyo Soo
المساهمون: Kang, Hyun Jae, Koo, Bon Kwon, Kim, Hyo Soo
بيانات النشر: Via Medica
سنة النشر: 2022
المجموعة: Seoul National University: S-Space
مصطلحات موضوعية: PERCUTANEOUS CORONARY INTERVENTION, ELEVATION MYOCARDIAL-INFARCTION, UNSTABLE ANGINA-PECTORIS, LONG-TERM OUTCOMES, ARTERY-DISEASE, GENDER-DIFFERENCES, NATIONAL-HEART, BARE-METAL, WOMEN, MEN, coronary artery disease, drug-eluting stent, sex difference, myocardial infarction
الوصف: Background: The contribution of sex and initial clinical presentation to the long-term outcomes in patients undergoing percutaneous coronary intervention (PCI) is still debated. Methods: Individual patient data from 5 Korean-multicenter drug-eluting stent (DES) registries (The GRAND-DES) were pooled. A total of 17,286 patients completed 3-year follow-up (5216 women and 12,070 men). The median follow-up duration was 1125 days (interquartile range 1097-1140 days), and the primary endpoint was cardiac death at 3 years. Results: The clinical indication for PCI was stable angina pectoris (SAP) in 36.8%, unstable angina pectoris (UAP) or non-ST-segment elevation myocardial infarction (NSTEMI) in 47.4%, and STEMI in 15.8%. In all groups, women were older and had a higher proportion of hypertension and diabetes mellitus compared with men. Women presenting with STEMI were older than women with SAP, with the opposite seen in men. There was no sex difference in cardiac death for SAP or UAP/NSTEMI. In STEMI patients, the incidence of cardiac death (7.9% vs. 4.4%, p = 0.001), all-cause mortality (11.1% vs. 6.9%, p = 0.001), and minor bleeding (2.2% vs. 1.2%, p = 0.043) was significantly higher in women. After multivariable adjustment, cardiac death was lower in women for UAP/NSTEMI (HR 0.69, 95% CI 0.53-0.89, p = 0.005), while it was similar for STEMI (HR 0.97, 95% CI 0.65-1.44, p = 0.884). Conclusions: There was no sex difference in cardiac death after PCI with DES for SAP and UAP/NSTEMI patients. In STEMI patients, women had worse outcomes compared with men; however, after the adjustment of confounders, female sex was not an independent predictor of mortality. ; N ; 1
نوع الوثيقة: article in journal/newspaper
اللغة: unknown
تدمد: 1897-5593
Relation: Cardiology Journal, Vol.30 No.1, pp.105-116; https://hdl.handle.net/10371/189992; 000913509300001; 2-s2.0-85149170142; 167700
DOI: 10.5603/CJ.a2021.0008
الاتاحة: https://hdl.handle.net/10371/189992
https://doi.org/10.5603/CJ.a2021.0008
رقم الانضمام: edsbas.34EC6D54
قاعدة البيانات: BASE
الوصف
تدمد:18975593
DOI:10.5603/CJ.a2021.0008