Academic Journal
The PARTNER trial of neoadjuvant olaparib with chemotherapy in triple-negative breast cancer
| العنوان: | The PARTNER trial of neoadjuvant olaparib with chemotherapy in triple-negative breast cancer |
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| المؤلفون: | Abraham, JE, Pinilla, K, Dayimu, A, Grybowicz, L, Demiris, N, Harvey, C, Drewett, LM, Lucey, R, Fulton, A, Roberts, AN, Worley, JR, Chhabra, A, Qian, W, Vallier, A, Hardy, RM, Chan, S, Hickish, T, Tripathi, D, Venkitaraman, R, Persic, M, Aslam, S, Glassman, D, Raj, S, Borley, A, Levitt, NC |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2024 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | PARTNER is a prospective, phase II–III, randomized controlled clinical trial that recruited patients with triple-negative breast cancer1, 2, who were germline BRCA1 and BRCA2 wild type3. Here we report the results of the trial. Patients (n = 559) were randomized on a 1:1 basis to receive neoadjuvant carboplatin–paclitaxel with or without 150 mg olaparib twice daily, on days 3 to 14, of each of four cycles (gap schedule olaparib, research arm) followed by three cycles of anthracycline-based chemotherapy before surgery. The primary end point was pathologic complete response (pCR)4, and secondary end points included event-free survival (EFS) and overall survival (OS)5. pCR was achieved in 51% of patients in the research arm and 52% in the control arm (P = 0.753). Estimated EFS at 36 months in the research and control arms was 80% and 79% (log-rank P > 0.9), respectively; OS was 90% and 87.2% (log-rank P = 0.8), respectively. In patients with pCR, estimated EFS at 36 months was 90%, and in those with non-pCR it was 70% (log-rank P < 0.001), and OS was 96% and 83% (log-rank P < 0.001), respectively. Neoadjuvant olaparib did not improve pCR rates, EFS or OS when added to carboplatin–paclitaxel and anthracycline-based chemotherapy in patients with triple-negative breast cancer who were germline BRCA1 and BRCA2 wild type. ClinicalTrials.gov ID: NCT03150576. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://ora.ox.ac.uk/objects/uuid:f5fb04be-f125-4ff9-a380-7f23cce27878; https://doi.org/10.1038/s41586-024-07384-2 |
| DOI: | 10.1038/s41586-024-07384-2 |
| الاتاحة: | https://doi.org/10.1038/s41586-024-07384-2 https://ora.ox.ac.uk/objects/uuid:f5fb04be-f125-4ff9-a380-7f23cce27878 |
| Rights: | info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| رقم الانضمام: | edsbas.34C9BF3B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41586-024-07384-2 |
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