Academic Journal
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity
| العنوان: | Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity |
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| المؤلفون: | Galderisi A., Trico D., Lat J., Samuels S., Weiss R., Van Name M., Pierpont B., Santoro N., Caprio S. |
| المساهمون: | Galderisi, A., Trico, D., Lat, J., Samuels, S., Weiss, R., Van Name, M., Pierpont, B., Santoro, N., Caprio, S. |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi del Molise: IRIS |
| مصطلحات موضوعية: | Diabete, Endocrinology, Glucose metabolism, Metabolism, Obesity |
| الوصف: | In youths with obesity, the gut hormone potentiation of insulin secretion — the incretin effect — is blunted. We explored the longitudinal impact of the incretin effect during pubertal transition on β cell function and insulin sensitivity. Youths with obesity and 2-hour glucose level ≥ 120 mg/dL underwent a 3-hour oral glucose-tolerance test (OGTT) and an isoglycemic i.v. glucose infusion to quantify the incretin effect. After 2 years, 30 of 39 participants had a repeated OGTT and were stratified into 3 tertiles according to the baseline incretin effect. The high–incretin effect group demonstrated a longitudinal increase in β cell function (disposition index, minimal model [DIMM]), with greater insulin sensitivity at follow-up and stable insulin secretion (φtotal). A lower incretin effect at baseline was associated with higher 1-hour and 2-hour glucose level at follow-up. The high–incretin effect group displayed a greater increase of GLP-17–36 than the moderate- and low-incretin group at baseline, while such a difference did not persist after 2 years. Glucagon suppression was reduced at follow-up in those with low-baseline incretin in respect to the high-incretin group. The incretin effect during pubertal transition affected the longitudinal trajectory of β cell function and weight in youths with obesity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:001111341800001; volume:8; issue:22; journal:JCI INSIGHT; https://hdl.handle.net/11695/134010; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85178383636 |
| DOI: | 10.1172/jci.insight.165709 |
| الاتاحة: | https://hdl.handle.net/11695/134010 https://doi.org/10.1172/jci.insight.165709 |
| رقم الانضمام: | edsbas.34C1ACDA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1172/jci.insight.165709 |
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