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Comparative bacterial proteomics: analysis of the core genome concept.

التفاصيل البيبلوغرافية
العنوان: Comparative bacterial proteomics: analysis of the core genome concept.
المؤلفون: Stephen J Callister, Lee Ann McCue, Joshua E Turse, Matthew E Monroe, Kenneth J Auberry, Richard D Smith, Joshua N Adkins, Mary S Lipton
المصدر: PLoS ONE, Vol 3, Iss 2, p e1542 (2008)
بيانات النشر: Public Library of Science (PLoS)
سنة النشر: 2008
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: Medicine, Science
الوصف: While comparative bacterial genomic studies commonly predict a set of genes indicative of common ancestry, experimental validation of the existence of this core genome requires extensive measurement and is typically not undertaken. Enabled by an extensive proteome database developed over six years, we have experimentally verified the expression of proteins predicted from genomic ortholog comparisons among 17 environmental and pathogenic bacteria. More exclusive relationships were observed among the expressed protein content of phenotypically related bacteria, which is indicative of the specific lifestyles associated with these organisms. Although genomic studies can establish relative orthologous relationships among a set of bacteria and propose a set of ancestral genes, our proteomics study establishes expressed lifestyle differences among conserved genes and proposes a set of expressed ancestral traits.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC2213561?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/da9164b8c107445e81995cf11fa2dac8
DOI: 10.1371/journal.pone.0001542
الاتاحة: https://doi.org/10.1371/journal.pone.0001542
https://doaj.org/article/da9164b8c107445e81995cf11fa2dac8
رقم الانضمام: edsbas.349CC34A
قاعدة البيانات: BASE
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0001542