Dissertation/ Thesis
Gut microbiota across early stages of synucleinopathy: from high-risk relatives, REM sleep behavior disorder to early Parkinson’s disease = 從高危親屬、快眼動睡眠期行為障礙患者、早期帕金森氏病患者了解早期突觸核蛋白變性疾病不同階段的腸道微生物群落 ; 從高危親屬、快眼動睡眠期行為障礙患者、早期帕金森氏病患者了解早期突觸核蛋白變性疾病不同階段的腸道微生物群落 ; Gut microbiota across early stages of synucleinopathy: from high-risk relatives, REM sleep behavior disorder to early Parkinson’s disease = Cong gao wei qin shu, kuai yan dong shui mian qi xing wei zhang ai huan zhe, zao qi Pajinsen shi bing huan zhe le jie zao qi tu chu he dan bai bian xing ji bing bu tong jie duan de chang dao wei sheng wu qun lo ; Cong gao wei qin shu, kuai yan dong shui mian qi xing wei zhang ai huan zhe, zao qi Pajinsen shi bing huan zhe le jie zao qi tu chu he dan bai bian xing ji bing bu tong jie duan de chang dao wei sheng wu qun lo
| العنوان: | Gut microbiota across early stages of synucleinopathy: from high-risk relatives, REM sleep behavior disorder to early Parkinson’s disease = 從高危親屬、快眼動睡眠期行為障礙患者、早期帕金森氏病患者了解早期突觸核蛋白變性疾病不同階段的腸道微生物群落 ; 從高危親屬、快眼動睡眠期行為障礙患者、早期帕金森氏病患者了解早期突觸核蛋白變性疾病不同階段的腸道微生物群落 ; Gut microbiota across early stages of synucleinopathy: from high-risk relatives, REM sleep behavior disorder to early Parkinson’s disease = Cong gao wei qin shu, kuai yan dong shui mian qi xing wei zhang ai huan zhe, zao qi Pajinsen shi bing huan zhe le jie zao qi tu chu he dan bai bian xing ji bing bu tong jie duan de chang dao wei sheng wu qun lo ; Cong gao wei qin shu, kuai yan dong shui mian qi xing wei zhang ai huan zhe, zao qi Pajinsen shi bing huan zhe le jie zao qi tu chu he dan bai bian xing ji bing bu tong jie duan de chang dao wei sheng wu qun lo |
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| المساهمون: | Huang, Bei (author.), Wing, Yun-Kwok (degree supervisor.), Chinese University of Hong Kong Graduate School. Division of Medical Sciences. (degree granting institution.) |
| سنة النشر: | 2021 |
| المجموعة: | The Chinese University of Hong Kong: CUHK Digital Repository / 香港中文大學數碼典藏 |
| مصطلحات موضوعية: | Gastrointestinal system--Microbiology, Nervous system--Degeneration, Parkinson's disease--Pathogenesis, Rapid eye movement sleep, Gastrointestinal Microbiome--physiology, Synucleinopathies--pathology, Parkinson Disease--pathology, REM Sleep Behavior Disorder--pathology |
| الوصف: | Background and aims: ; Recent studies revealed distinct composition of gut microbiota in subjects with Parkinson’s disease (PD), which suggested the involvement of gut microbiota and microbiota-gut-brain axis in the pathogenesis of PD. Nonetheless, the roles of gut microbiota at the early stages of synucleinopathy, REM sleep behavior disorder (RBD) and their relatives, and its interactions with the prodromal markers of PD are still unclear. In this study, we aim to identify the colonic bacterial compositions in subjects with early PD, RBD, first-degree relatives of RBD (RBD-FDR), and healthy controls, and further correlate the abundances of these microbiota with clinical biomarkers. ; Methods: ; This is a case–control study based on our prospective longitudinal family cohort of RBD and controls. Early PD was defined as onset of PD symptoms less than five years, while the diagnoses of RBD were confirmed by video-polysomnography. Subjects underwent face-to-face clinical assessments. Fecal microbial community composition was generated by sequencing the third and fourth variable regions (V3- 4) of the microbial 16S ribosomal RNA gene. ; Results: ; A total of 228 controls, 125 RBD-FDR, 154 subjects with RBD and 34 subjects with early PD were recruited into study. Microbial analysis was performed in 64 controls, 83 RBD-FDR, 80 RBD and 15 early PD subjects. ; 1) Neurodegenerative biomarkers. The prevalence of functional constipation (6.3 vs 13.3 vs 46.7 vs 67.6 %, P < 0.001), olfactory impairment (15.8 vs 22.5 vs 73.6 vs 84.8 %, P < 0.001) increased from controls, RBD-FDR, RBD to early PD. Total likelihood ratio (LR) of prodromal PD were highest in RBD, followed by RBD-FDR and controls. RBD-FDR with RBD features (RBD-FDRᴿᴮᴰ⁺, n = 28) reported more constipation (P = 0.007), higher total LR of prodromal PD (P = 0.04) and prevalence of probable prodromal PD (P = 0.01) when compared with RBD-FDR who were devoid of RBD symptoms (RBD-FDRᴿᴮᴰ⁻, n = 97). ; 2) Microbial composition. Subjects with RBD showed comparable ... |
| نوع الوثيقة: | thesis |
| وصف الملف: | electronic resource; remote; 1 online resource (xxii, 164 leaves) : illustrations (some color); computer; online resource |
| اللغة: | English Chinese |
| Relation: | cuhk:2651793; local: ETD920210659; local: 991040107918103407; https://julac.hosted.exlibrisgroup.com/primo-explore/search?query=addsrcrid,exact,991040107918103407,AND&tab=default_tab&search_scope=All&vid=CUHK&mode=advanced&lang=en_US; https://repository.lib.cuhk.edu.hk/en/item/cuhk-2651793 |
| الاتاحة: | https://julac.hosted.exlibrisgroup.com/primo-explore/search?query=addsrcrid,exact,991040107918103407,AND&tab=default_tab&search_scope=All&vid=CUHK&mode=advanced&lang=en_US https://repository.lib.cuhk.edu.hk/en/item/cuhk-2651793 |
| Rights: | Use of this resource is governed by the terms and conditions of the Creative Commons "Attribution-NonCommercial-NoDerivatives 4.0 International" License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| رقم الانضمام: | edsbas.3479A02B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |