Academic Journal
Monitoring brain tissue oxygen tension in brain-injured patients reveals hypoxic episodes in normal-appearing and in peri-focal tissue
| العنوان: | Monitoring brain tissue oxygen tension in brain-injured patients reveals hypoxic episodes in normal-appearing and in peri-focal tissue |
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| المؤلفون: | Longhi L., Pagan F., Valeriani V., Magnoni S., Zanier E. R., Conte V., Branca V., Stocchetti N. |
| المساهمون: | Longhi, L., Pagan, F., Valeriani, V., Magnoni, S., Zanier, E. R., Conte, V., Branca, V., Stocchetti, N. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Brain hypoxia, Brain oxygenation, Pathophysiology, PtiO, Secondary insult, Traumatic brain injury |
| Time: | 2 |
| الوصف: | Objective: We compared brain tissue oxygen tension (PtiO2) measured in peri-focal and in normal-appearing brain parenchyma on computerized tomography (CT) in patients following traumatic brain injury (TBI). Design: Prospective observational study. Setting: Neurointensive care unit. Patients and participants: Thirty-two consecutive TBI patients were subjected to PtiO 2 monitoring. Interventions: Peri-focal tissue was identified by the presence of a hypodense area of the contusion and/or within 1 cm from the core of the contusion. The position of the tip of the PtiO2 probe was assessed at follow-up CT scan. Measurements and results: Mean PtiO2 in the peri-contusional tissue was 19.7 ± 2.1 mmHg and was lower than PtiO2 in normal-appearing tissue (25.5 ± 1.5 mmHg, p < 0.05), despite a greater cerebral perfusion pressure (CPP) (73.7 ± 2.3 mmHg vs. 67.4 ± 1.4 mmHg, p < 0.05). We observed both in peri-focal tissue and in normal-appearing tissue episodes of brain hypoxia (PtiO 2 < 20 mmHg for at least 10 min), whose median duration was longer in peri-focal tissue than in normal-appearing tissue (51% vs. 34% of monitoring time, p < 0.01). In peri-focal tissue, we observed a progressive PtiO 2 increase from pathologic to normal values (p < 0.01). Conclusions: Multiple episodes of brain hypoxia occurred over the first 5 days following severe TBI. PtiO2 was lower in peri-contusional tissue than in normal-appearing tissue. In peri-contusional tissue, a progressive increase of PtiO2 from pathologic to normal values was observed over time, suggestive of an improvement at microcirculatory level. © 2007 Springer-Verlag. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | volume:33; issue:12; firstpage:2136; lastpage:2142; numberofpages:7; journal:INTENSIVE CARE MEDICINE; https://hdl.handle.net/11388/325695; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-36448993306 |
| DOI: | 10.1007/s00134-007-0845-2 |
| الاتاحة: | https://hdl.handle.net/11388/325695 https://doi.org/10.1007/s00134-007-0845-2 |
| رقم الانضمام: | edsbas.346996D3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00134-007-0845-2 |
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