Academic Journal
Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion
| العنوان: | Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion |
|---|---|
| المؤلفون: | Brotherton, Emma E., Neal, Thomas J., Kaldybekov, Daulet B., Smallridge, Mark J., Khutoryanskiy, Vitaliy V., Armes, Steven P. |
| بيانات النشر: | Royal Society of Chemistry |
| سنة النشر: | 2022 |
| المجموعة: | CentAUR: Central Archive at the University of Reading |
| الوصف: | A series of thermoresponsive diblock copolymer worm gels is prepared via reversible addition–fragmentation chain transfer (RAFT) aqueous dispersion polymerization of 2-hydroxypropyl methacrylate using a water-soluble methacrylic precursor bearing pendent cis-diol groups. Selective oxidation using an aqueous solution of sodium periodate affords the corresponding aldehyde-functional worm gels. The aldehyde groups are located within the steric stabilizer chains and the aldehyde content can be adjusted by varying the periodate/cis-diol molar ratio. These aldehyde-functional worm gels are evaluated in terms of their mucoadhesion performance with the aid of a fluorescence microscopy-based assay. Using porcine urinary bladder mucosa as a model substrate, we demonstrate that these worm gels offer a comparable degree of mucoadhesion to that afforded by chitosan, which is widely regarded to be a ‘gold standard’ positive control in this context. The optimum degree of aldehyde functionality is approximately 30%: lower degrees of functionalization lead to weaker mucoadhesion, whereas higher values compromise the desirable thermoresponsive behavior of these worm gels. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://centaur.reading.ac.uk/105426/1/Aldehyde%20worm%20gels-ChemSci-2022.pdf; Brotherton, E. E., Neal, T. J., Kaldybekov, D. B. , Smallridge, M. J., Khutoryanskiy, V. V. orcid:0000-0002-7221-2630 and Armes, S. P. (2022) Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion. Chemical Science, 13 (23). pp. 6888-6898. ISSN 1478-6524 doi: https://doi.org/10.1039/D2SC02074B |
| الاتاحة: | https://centaur.reading.ac.uk/105426/ https://centaur.reading.ac.uk/105426/1/Aldehyde%20worm%20gels-ChemSci-2022.pdf |
| Rights: | cc_by |
| رقم الانضمام: | edsbas.34493C17 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |