التفاصيل البيبلوغرافية
| العنوان: |
Impact of Cortisol on Reduction in Muscle Strength and Mass: A Mendelian Randomization Study |
| المؤلفون: |
Shunsuke Katsuharake, Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Yayoi Matsuda, Norifusa Iwahashi, Hiroki Kaneko, Masatoshi Ogata, Tazuru Fukumoto, Eriko Terada, Ryuichi Sakamoto, Yoshihiro Ogawa |
| بيانات النشر: |
Zenodo |
| سنة النشر: |
2021 |
| المجموعة: |
Zenodo |
| الوصف: |
Purpose: Prolonged exposure to pathological cortisol, as in Cushing’s syndrome causes various age-related disorders including sarcopenia. However, it is unclear whether mild cortisol excess, for example, accelerates sarcopenia due to aging or chronic stress. We performed a Mendelian randomization (MR) analysis to assess whether cortisol was associated with muscle strength and mass. Methods: Three single nucleotide polymorphisms associated with plasma cortisol concentrations in the CORtisol NETwork consortium (n = 12,597) were used as instrumental variables. Summary statistics with traits of interest were obtained from relevant genome-wide association studies (GWAS). Functional Mapping and Annotation (FUMA) was used for functional assessment of GWAS for cortisol. Results: One standard deviation (SD) increase in cortisol was associated with SD reduction in grip strength (estimate, -0.031; 95% confidence interval [CI] -0.052 ~ -0.011; P = 0.003), whole-body lean mass (estimate, -0.032; 95%CI, -0.050 ~ -0.015; P = 3e-04), and appendicular lean mass (estimate, -0.031; 95%CI, -0.058 ~ -0.004; P = 0.023). The association of cortisol with grip strength and lean mass was observed in women but not in men. The association was attenuated after adjusting for fasting glucose, which was the top mediator for the associations in the MR-Bayesian model averaging analysis. The ankyrin repeat and SOCS box protein-2 gene , a putative negative regulator of muscle mass, was identified as one of the prioritized genes. Conclusion: This MR study provides evidence for the association of cortisol with a reduction in muscle strength and mass, thereby suggesting the impact of cortisol on the development of sarcopenia. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://doi.org/10.5281/zenodo.5149263; https://doi.org/10.5281/zenodo.5149264; oai:zenodo.org:5149264 |
| DOI: |
10.5281/zenodo.5149264 |
| الاتاحة: |
https://doi.org/10.5281/zenodo.5149264 |
| Rights: |
info:eu-repo/semantics/openAccess ; Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode |
| رقم الانضمام: |
edsbas.33EBA2AC |
| قاعدة البيانات: |
BASE |