التفاصيل البيبلوغرافية
| العنوان: |
Antiblood Cell Adhesion of Mussel-Inspired Chondroitin Sulfate- and Caffeic Acid-Modified Polycarbonate Membranes |
| المؤلفون: |
Rajakumari Krishnamoorthi (12338494), Rajeshkumar Anbazhagan (1418656), Darieo Thankachan (12338497), Van Thi Thuy Dinh (14313478), Hsieh-Chih Tsai (1418650), Juin-Yih Lai (1907980), Chih-Feng Wang (1792726) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Cell Biology, Biotechnology, Immunology, Hematology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, − 32 mv, water contact angle, lower fibrinogen adsorption, linked immunosorbent assay, negative surface charge, excellent antiadhesion properties, modified polycarbonate membranes, obtained results proved, michael addition reaction, inspired chondroitin sulfate, antiblood cell adhesion, modified pc membrane, chondroitin sulfate, cell adhesion, membrane surface, antiadhesion property, pc membrane, zeta potential, work disclosed, versatile modification, schiff base |
| الوصف: |
We fabricated a mussel-inspired hemocompatible polycarbonate membrane (PC) modified by the cross-linking of chondroitin sulfate and caffeic acid polymer using CA-CS via a Schiff base and Michael addition reaction and named it CA-CS-PC. The as-fabricated CA-CS-PC membrane shows excellent hydrophilicity with a water contact angle of 0° and a negative surface charge with a zeta potential of −32 mV. The antiadhesion property of the CA-CS-modified PC membrane was investigated by enzyme-linked immunosorbent assay (ELISA), using human plasma protein fibrinogen adsorption studies, and proved to have excellent antiadhesion properties, because of the lower fibrinogen adsorption. In addition, the CA-CS-PC membrane also shows enhanced hemocompatibility. Finally, blood cell attachment tests of the CA-CS-PC membrane were observed by CLSM and SEM, and the obtained results proved that CA-CS-PC effectively resisted cell adhesion, such as platelets and leucocytes. Therefore, this work disclosed a new way to design a simple and versatile modification of the membrane surface by caffeic acid and chondroitin sulfate and apply it for cell adhesion. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Antiblood_Cell_Adhesion_of_Mussel-Inspired_Chondroitin_Sulfate-_and_Caffeic_Acid-Modified_Polycarbonate_Membranes/21799960 |
| DOI: |
10.1021/acs.langmuir.2c01688.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.langmuir.2c01688.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.33E5A8FB |
| قاعدة البيانات: |
BASE |