Academic Journal
Which Patients with Prostate Cancer and Lymph Node Uptake at Preoperative Prostate-specific Membrane Antigen Positron Emission Tomography/Computerized Tomography Scan Are at a Higher Risk of Prostate-specific Antigen Persistence After Radical Prostatectomy? Identifying Indicators of Systemic Disease by Integrating Clinical, Magnetic Resonance Imaging, and Functional Imaging Parameters
| العنوان: | Which Patients with Prostate Cancer and Lymph Node Uptake at Preoperative Prostate-specific Membrane Antigen Positron Emission Tomography/Computerized Tomography Scan Are at a Higher Risk of Prostate-specific Antigen Persistence After Radical Prostatectomy? Identifying Indicators of Systemic Disease by Integrating Clinical, Magnetic Resonance Imaging, and Functional Imaging Parameters |
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| المؤلفون: | Mazzone, Elio, Gandaglia, Giorgio, Robesti, Daniele, Rajwa, Pawel, Gomez Rivas, Juan, Ibáñez, Laura, Soeterik, Timo F W, Bianchi, Lorenzo, Afferi, Luca, Kesch, Claudia, Darr, Christopher, Guo, Hongqian, Zhuang, Junlong, Zattoni, Fabio, Fendler, Wolfgang P, Amparore, Daniele, Huebner, Nicolai A, Giesen, Alexander, Joniau, Steven, Schiavina, Riccardo, Brunocilla, Eugenio, Mattei, Agostino, Dal Moro, Fabrizio, Moreno Sierra, Jesus, Porpiglia, Francesco, Picchio, Maria, Chiti, Arturo, van den Bergh, Roderick, Shariat, Shahrokh F, Montorsi, Francesco, Briganti, Alberto |
| المساهمون: | Mazzone, Elio, Gandaglia, Giorgio, Robesti, Daniele, Rajwa, Pawel, Gomez Rivas, Juan, Ibáñez, Laura, Soeterik, Timo F W, Bianchi, Lorenzo, Afferi, Luca, Kesch, Claudia, Darr, Christopher, Guo, Hongqian, Zhuang, Junlong, Zattoni, Fabio, Fendler, Wolfgang P, Amparore, Daniele, Huebner, Nicolai A, Giesen, Alexander, Joniau, Steven, Schiavina, Riccardo, Brunocilla, Eugenio, Mattei, Agostino, Dal Moro, Fabrizio, Moreno Sierra, Jesu, Porpiglia, Francesco, Picchio, Maria, Chiti, Arturo, van den Bergh, Roderick, Shariat, Shahrokh F, Montorsi, Francesco, Briganti, Alberto |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Multiparametric magnetic resonance imaging, Nomogram, Prostate cancer, Prostate-specific antigen persistence, Prostate-specific membrane antigen positron emission tomography, Risk category |
| الوصف: | Background: The role of local therapies including radical prostatectomy (RP) in prostate cancer (PCa) patients with clinical lymphadenopathies on prostate-specific membrane antigen (PSMA) positron emission tomography/computerized tomography (PET/CT) has scarcely been explored. Limited data are available to identify men who would benefit from RP; on the contrary, those more likely to benefit already have systemic disease. Objective: We aimed to assess the predictors of prostate-specific antigen (PSA) persistence in surgically managed PCa patients with lymphadenopathies on a PSMA PET/CT scan by integrating clinical, magnetic resonance imaging (MRI), and PSMA PET/CT parameters. Design, setting, and participants: We identified 519 patients treated with RP and extended lymph node dissection, and who received preoperative PSMA PET between 2017 and 2022 in nine referral centers. Among them, we selected 88 patients with nodal uptake at preoperative PSMA PET (miTxN1M0). Outcome measurements and statistical analysis: The outcome was PSA persistence, defined as a PSA value of ≥0.1 ng/ml at the first measurement after surgery. Multivariable logistic regression models tested the predictors of PSA persistence. Covariates consisted of biopsy International Society of Urological Pathology (ISUP) grade group, clinical stage at MRI, and number of positive spots at a PET/CT scan. A regression tree analysis stratified patients into risk groups based on preoperative characteristics. Results and limitations: Overall, lymph node invasion (LNI) was detected in 63 patients (72%) and 32 (36%) experienced PSA persistence after RP. At multivariable analyses, having more than two lymph nodal positive findings at PSMA PET, seminal vesicle invasion (SVI) at MRI, and ISUP grade group >3 at biopsy were independent predictors of PSA persistence (all p<0.05). At the regression tree analysis, patients were stratified in four risk groups according to biopsy ISUP grade, number of positive findings at PET/CT, and clinical stage at MRI. The model ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37689506; info:eu-repo/semantics/altIdentifier/wos/WOS:001223937100001; volume:7; issue:2; firstpage:231; lastpage:240; numberofpages:10; journal:EUROPEAN UROLOGY ONCOLOGY; https://hdl.handle.net/20.500.11768/155416; https://www.sciencedirect.com/science/article/pii/S2588931123001736?via=ihub |
| DOI: | 10.1016/j.euo.2023.08.010 |
| الاتاحة: | https://hdl.handle.net/20.500.11768/155416 https://doi.org/10.1016/j.euo.2023.08.010 https://www.sciencedirect.com/science/article/pii/S2588931123001736?via=ihub |
| رقم الانضمام: | edsbas.33E55FDB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.euo.2023.08.010 |
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