التفاصيل البيبلوغرافية
| العنوان: |
Patent Ductus Arteriosus in Premature Infants: Clinical Trials and Equipoise |
| المؤلفون: |
Liguori, Macrina B., Ali, Sanoj K. M., Gupta, Samir, Laughon, Matthew, Bussman, Neidin, Colaizy, Tarah, Hundscheid, Tim, Phad, Nikant, Clyman, Ronald, de Boode, Willem-Pieter, de Waal, Koert, El-Khuffash, Afif |
| المساهمون: |
The University of Newcastle. College of Health, Medicine & Wellbeing, School of Medicine and Public Health |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2023 |
| المجموعة: |
NOVA: The University of Newcastle Research Online (Australia) |
| مصطلحات موضوعية: |
neonatology, research ethics, bias, study design, symposium summary, hemodynamics |
| الوصف: |
Persistent patency of the ductus arteriosus is common in premature infants, yet patent ductus arteriosus (PDA) management varies widely. In observational studies, PDA is associated with prolonged assisted ventilation, bronchopulmonary dysplasia (BPD), pulmonary hemorrhage, necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), periventricular leukomalacia, cerebral palsy, renal impairment, and mortality. 1-7 These associations led many clinicians to treat a PDA in all preterm infants. However randomized controlled trials (RCTs) of PDA treatment have failed to demonstrate significant reductions in clinically important outcomes. As an example, prophylactic indomethacin trials (for reducing IVH) demonstrate that indomethacin reduces incidence of symptomatic PDA, need for ligation, and IVH, but has no effect on BPD, NEC, long-term neurodevelopmental impairment (NDI) or death. 1,8 Thus, it is unclear if PDA is part of the causal pathway for development of these morbidities. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
0022-3476 |
| Relation: |
Journal of Pediatrics Vol. 261, Issue October 2023, no. 113532; http://hdl.handle.net/1959.13/1483954; uon:51236 |
| الاتاحة: |
http://hdl.handle.net/1959.13/1483954 |
| رقم الانضمام: |
edsbas.33E142F |
| قاعدة البيانات: |
BASE |