Academic Journal
A Preliminary Investigation on Plasma Cell Adhesion Molecules Levels by Protein Microarray Technology in Major Depressive Disorder
| العنوان: | A Preliminary Investigation on Plasma Cell Adhesion Molecules Levels by Protein Microarray Technology in Major Depressive Disorder |
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| المؤلفون: | Liu, Wanying, Zheng, Yanqun, Zhang, Fuxu, Zhu, Mo, Guo, Qian, Xu, Hua, Liu, Caiping, Chen, Haiying, Wang, Xiaoliang, Hu, Yao, Zhang, Tianhong, Lin, Zhiguang, Zhang, Chen, Li, Guanjun, Jiang, Kaida, Liu, Xiaohua |
| المساهمون: | National Natural Science Foundation of China, Shanghai Municipal Health and Family Planning Commission, Shanghai Shenkang Hospital Development Center, Shanghai Clinical Research Center |
| المصدر: | Frontiers in Psychiatry ; volume 12 ; ISSN 1664-0640 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2021 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Objectives: Major depressive disorder (MDD) is a serious mental disorder, and there is a great difficulty to diagnose and treat. Hitherto, relatively few studies have explored the correlation between the levels of plasma cell adhesion molecules and MDD. Methods: Thirty outpatients with acute episodes of MDD in Shanghai Mental Health Center and 34 healthy volunteers from the community were recruited as subjects. Protein microarray technology was applied to compared the differences in plasma levels of 17 kinds of adhesion molecular proteins between the two groups. Meanwhile, the diagnostic value of different proteins in depression was discussed by using the receiver operating characteristic curve. Results: The levels of Carcinoembryonic Antigen Related Cell Adhesion Molecule-1(CEACAM-1) and Neural Cell Adhesion Molecule (NrCAM) in MDD patients were significantly higher than those in healthy controls ( P < 0.05). The area under ROC curve of CEACAM-1 combined with NrCAM was 0.723, with the sensitivity 0.800 and the specificity 0.676. Conclusion: The plasma levels of CEACAM-1 and NrCAM were significantly up-regulated in MDD, and their combined application was of potential diagnostic value, deserving to expand the sample size for further verification. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fpsyt.2021.627469 |
| DOI: | 10.3389/fpsyt.2021.627469/full |
| الاتاحة: | http://dx.doi.org/10.3389/fpsyt.2021.627469 https://www.frontiersin.org/articles/10.3389/fpsyt.2021.627469/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.33C32711 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fpsyt.2021.627469 |
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