Academic Journal
Impact of human immunodeficiency virus type 1 subtypes on virologic response and emergence of drug resistance among children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 trial
| العنوان: | Impact of human immunodeficiency virus type 1 subtypes on virologic response and emergence of drug resistance among children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 trial |
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| المؤلفون: | Pillay D., Walker A. S., Gibb D. M., De Rossi A., Kaye S., Ait-Khaled M., Munoz-Fernandez M., Babiker A., Boucher C., Loveday C., Fernandez M. M., Rouzioux C., Aboulker J. -P., Compagnucci A., Darbyshire J., Debre M., Gersten M., Giaquinto C., Jones A., Dunn D., Harper L., Johnson D., Kelleher P., Mc Gee L., Newberry A., Poland A., Eliette V., Leonardo S., Saidi Y., Blanche S., Bohlin A. B., Butler K., Castelli-Gattinara G., Clayden P., Faye A., Griscelli C., Grosch-Worner I., Levy J., Lyall H., Pena M. M., Nadal D., Peckham C., Amador J. T. R., Rosado L., Rudin C., Scherpbier H., Sharland M., Tovo P. A., Tudor-Williams G., Volny-Anne A., Wintergerst U., Hainaut M., Peltier A., Zissis G., Negra M. D., Queiroz W., Feitosa L. P., Oliveira D., Mechinaud F., Billaudel S., Ferre V., Weigel R., Seel K., Feiterna-Sperling C., Muller C., Wahn V., Niehues T., Ndagijimana J., Horneff G., Vente N., Ganschow R., Simon T., Pfister H., Notheis G., Strotmann G., Schlieben S., Hayes E., O'Mara M., Byrne J. M., Battisti L., Duse M., Timpano S., Uberti E., Crispino P., Carrara P., Fomia F., Manca A., Galli L., De Martino M., Fioredda F., Pontali E., Cellini M., Baraldi C., Portolani M., Meacci M., Pietrosemoli P., Guarino A., Spagnuola M. I., Canani R. B., Laccetti P., Gobbo M., Giacomet V., D'Elia R., Zanchetta M., Caselli D., Maccabruni A., Cattaneo E., Landini V., Bernardi S., Krzysztofiak A., Tancredi C., Rossi P., Pansani L., Palomba E., Gabiano C., Mazza A., Rossetti G., Nicolin R., Timillero A., Candeias F., Santos G., Ribeiro M. L. R., Almeida M. C., Lourenco M. H., Antunes R., Pena M. J. M., Santos P. M., Calavia L. C., Delgado O., Matamoros N., Foot A., Kershaw H., Caul O., Tarnow-Mordi W., Petrie J., Mc Intyre P., Appleyard K., Sloper K., Shah V., Aali A., Mok J., Russell R., Burns S., Novelli V., Klein N., Ewen S., Ball C., Himid K., Nayagam D., Graham D., Zuckerman M., Bracken P., Cooper E., Fisher T., Barrie R., Someren V. V., Moshal K., Gundlach T., Norman J., Richardson M., Donaghy S., Booth J., Shipp A., Butcher D., White J., Head S., Stainsby C., Mont G. D., O'Shea S., Tilsey A., Finn A., Choo S., Lakshman R., Bell G., Siddens A. |
| المساهمون: | D. Pillay, A.S. Walker, D.M. Gibb, A. De Rossi, S. Kaye, M. Ait-Khaled, M. Munoz-Fernandez, A. Babiker, C. Boucher, C. Loveday, M.M. Fernandez, C. Rouzioux, J.-. Aboulker, A. Compagnucci, J. Darbyshire, M. Debre, M. Gersten, C. Giaquinto, A. Jone, D. Dunn, L. Harper, D. Johnson, P. Kelleher, L. Mc Gee, A. Newberry, A. Poland, V. Eliette, S. Leonardo, Y. Saidi, S. Blanche, A.B. Bohlin, K. Butler, G. Castelli-Gattinara, P. Clayden, A. Faye, C. Griscelli, I. Grosch-Worner, J. Levy, H. Lyall, M.M. Pena, D. Nadal, C. Peckham, J.T.R. Amador, L. Rosado, C. Rudin, H. Scherpbier, M. Sharland, P.A. Tovo, G. Tudor-William, A. Volny-Anne, U. Wintergerst, M. Hainaut, A. Peltier, G. Zissi, M.D. Negra, W. Queiroz, L.P. Feitosa, D. Oliveira, F. Mechinaud, S. Billaudel, V. Ferre, R. Weigel, K. Seel, C. Feiterna-Sperling, C. Muller, V. Wahn, T. Niehue, J. Ndagijimana, G. Horneff, N. Vente, R. Ganschow, T. Simon, H. Pfister, G. Nothei, G. Strotmann, S. Schlieben, E. Haye, M. O'Mara, J.M. Byrne, L. Battisti, M. Duse, S. Timpano, E. Uberti, P. Crispino, P. Carrara, F. Fomia, A. Manca, L. Galli, M. De Martino, F. Fioredda, E. Pontali, M. Cellini, C. Baraldi, M. Portolani, M. Meacci, P. Pietrosemoli, A. Guarino, M.I. Spagnuola, R.B. Canani, P. Laccetti |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2002 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Antiviral Agent, Child, Preschool, Drug Resistance, Drug Therapy, Combination, HIV Infection, HIV Protease Inhibitor, HIV-1, Human, Nelfinavir, RNA, Viral, Reverse Transcriptase Inhibitors, Settore MED/38 - Pediatria Generale e Specialistica |
| الوصف: | The association between virologic response and human immunodeficiency virus type 1 (HIV-1) subtype was investigated in 113 HIV-1-infected children randomly assigned to receive zidovudine plus lamivudine, zidovudine plus abacavir, or lamivudine plus abacavir in the Paediatric European Network for Treatment of AIDS (PENTA) 5 trial. Symptomatic children (n = 68) also received nelfinavir; asymptomatic children (n = 45) were randomly assigned to receive nelfinavir or placebo. HIV-1 subtypes A, B, C, D, F, G, H, A/E, and A/G were found in 15%, 41%, 16%, 9%, 5%, 2%, 1%, 5%, and 7% of the children, respectively. Resistance assay failure rates were higher for non-B subtypes than for B subtypes (genotype, P = .01; phenotype, P = .02). HIV-1 subtype was not associated with virologic response at 24 and 48 weeks after initiation of treatment. No differences were observed in the frequency of development of resistance mutations L90M (P = 1.00) and D30N (P = .61) in B and non-B viruses. In conclusion, no evidence that subtype determined virologic response to therapy was found. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | volume:186; issue:5; firstpage:617; lastpage:625; numberofpages:9; journal:ANTIVIRAL THERAPY; http://hdl.handle.net/2434/728842; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0036721511 |
| DOI: | 10.1086/342680 |
| الاتاحة: | http://hdl.handle.net/2434/728842 https://doi.org/10.1086/342680 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.33B21BDB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1086/342680 |
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