Academic Journal
Role of potassium channels in the frequency-dependent activity of regenerating nerves
| العنوان: | Role of potassium channels in the frequency-dependent activity of regenerating nerves |
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| المؤلفون: | Mert T., Gunay I., Daglioglu Y.K. |
| المساهمون: | Çukurova Üniversitesi |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Fast and slow potassium channels, Hyperpolarizing afterpotential, Nerve injury, Nerve regeneration, Slow sodium currents |
| الوصف: | PubMedID: 15452364 ; After a peripheral nerve injury, ion channel organization and the electrical properties of nerve fibers drastically change during the regeneration process. The present study was designed to compare the frequency-dependent characteristics of regenerating nerves in the presence of 4-aminopyridine (4-AP) and tetraethylammonium (TEA). The results showed that increasing the stimulus frequency produced a greater impulse blockade (frequency-dependent block - FDB) and distinct hyperpolarizing afterpotentials (HAPs) in regenerating nerves. In particular, regenerating sciatic nerves 15 days postcrush (dpc) were more sensitive to the frequency-dependent stimulations than 38-dpc and intact nerves in the presence or absence of drugs. The frequency-dependent effects of TEA on the compound action potentials (CAPs) appeared when TEA was applied to 4-AP-treated nerves. This shows that TEA-sensitive channels may not be masked by the myelin. 4-AP was here found to have more pronounced frequency-dependent effects on regenerating nerves than on intact nerves. Delayed depolarization (in 38-dpc: 22.6 ± 1.3 mV and 47.52 ± 3.63 ms, in intact: 12.0 ± 1.9 mV and 88.51 ± 4.72 ms) elicited by 4-AP resulted in an increase in FDBs and HAP amplitudes. These results suggest that 4-AP-sensitive channels may play important roles in frequency-dependent nerve conduction. Consequently, regenerating or myelin damaged nerves are more sensitive to repetitive firing with or without drug. An understanding of the frequencydependent properties of regenerating nerves may be of value in the treatment of the nerve diseases. Copyright © 2004 S. Karger AG, Basel. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0031-7012 |
| Relation: | Pharmacology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.1159/000080100; https://hdl.handle.net/20.500.12605/19715; 72; 157; 166 |
| DOI: | 10.1159/000080100 |
| الاتاحة: | https://hdl.handle.net/20.500.12605/19715 https://doi.org/10.1159/000080100 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.33B13F70 |
| قاعدة البيانات: | BASE |
| تدمد: | 00317012 |
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| DOI: | 10.1159/000080100 |