Academic Journal
IgG anti-high density lipoprotein antibodies are elevated in abdominal aortic aneurysm and associated with lipid profile and clinical features
| العنوان: | IgG anti-high density lipoprotein antibodies are elevated in abdominal aortic aneurysm and associated with lipid profile and clinical features |
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| المؤلفون: | RodrÃguez-Carrio, J., Lindholt, J.S., Canyelles, Marina, MartÃnez-López, Diego, Tondo, Mireia, Blanco-Colio, Luis Miguel, Michel, J.B., Escolà -Gil, Joan Carles, Suárez, A., MartÃn-Ventura, J.L., Universitat Autònoma de Barcelona |
| سنة النشر: | 2020 |
| المجموعة: | Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: | Abdominal aortic aneurysm, Autoantibodies, Autoimmunity, HDLc |
| الوصف: | High-density lipoproteins cholesterol (HDLc) levels are decreased in abdominal aortic aneurysm (AAA), which is hallmarked by autoimmunity and lipid aortic deposits. To investigate whether IgG anti-HDL antibodies were present in AAA and their potential association with clinical features, IgG anti-HDL and total IgG along with HDLc plasma levels were measured in 488 AAA patients and 184 controls from the Viborg Vascular (VIVA) study, and in tissue-conditioned media from AAA intraluminal thrombus and media layer samples compared to control aortas. Higher IgG anti-HDL levels were found in AAA compared to controls, even after correcting for total IgG, and after adjusting for potential confounders. IgG anti-HDL levels were correlated with aortic diameter in univariate and adjusted multivariate analyses. IgG anti-HDL antibodies were negatively associated with HDLc levels before and after correcting for potential confounders. Increased anti-HDL antibodies were identified in tissue-conditioned media from AAA samples compared to healthy aortas, with higher levels being observed in the media layer. In conclusion, increased IgG anti-HDL levels (both in plasma and in tissue) are linked to AAA, associated with aortic diameter and HDLc levels. These data suggest a potential immune response against HDL in AAA and support an emerging role of anti-HDL antibodies in AAA. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 20770383 31888089 |
| Relation: | Ministerio de EconomÃa y Competitividad PI16/00113; Ministerio de EconomÃa y Competitividad FJCI-2015-23849; Journal of clinical medicine; Vol. 9 Núm. 1 (january 2020), p. 67; https://ddd.uab.cat/record/284429; urn:10.3390/jcm9010067; urn:oai:ddd.uab.cat:284429; urn:scopus_id:85083890538; urn:articleid:20770383v9n1p67; urn:pmid:31888089; urn:pmc-uid:7019833; urn:pmcid:PMC7019833; urn:oai:pubmedcentral.nih.gov:7019833 |
| الاتاحة: | https://ddd.uab.cat/record/284429 |
| Rights: | open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.33457795 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20770383 31888089 |
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