Academic Journal
Basophil response and the induction of a tolerance in venom immunotherapy: a long‐term sting challenge study
| العنوان: | Basophil response and the induction of a tolerance in venom immunotherapy: a long‐term sting challenge study |
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| المؤلفون: | Eržen, R., Košnik, M., Šilar, M., Korošec, P. |
| المصدر: | Allergy ; volume 67, issue 6, page 822-830 ; ISSN 0105-4538 1398-9995 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2012 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background There is no in vitro test to predict the induction of long‐term tolerance in patients treated with venom immunotherapy ( VIT ). The aim of this study was to investigate whether immunotherapy‐induced changes in basophil responsiveness reflect a state of protection and the induction of a tolerance. Methods Twenty‐three patients with allergic reaction after H ymenoptera sting (11 wasp and 12 honeybee) were treated with VIT . In all patients, a CD 63 basophil activation test was performed before the beginning of immunotherapy, after 1 year and after completing 4–6.5 years of immunotherapy (approximately 1 year after stopping). The tolerance was then evaluated by a sting challenge test. The basophil activation test was repeated 3–6 months after the challenge. Results Twenty‐two subjects showed a negative sting challenge, and one subject, a positive sting challenge. Allergen‐specific basophil response remained unchanged after 1 year of immunotherapy. However, after immunotherapy, a significant and approximately fourfold decrease was demonstrated in all tolerant subjects mainly in response to submaximal 0.1 μg/ml allergen concentration. This depression was sustained and did not change with the sting challenge test. In a nontolerant patient with a positive sting challenge, basophil response did not change. Conclusions Our results suggest that the depression of allergen‐specific basophil response seems to be associated with the induction of a tolerance after completing a course of VIT . |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1398-9995.2012.02817.x |
| الاتاحة: | https://doi.org/10.1111/j.1398-9995.2012.02817.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1398-9995.2012.02817.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1398-9995.2012.02817.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.33313818 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1398-9995.2012.02817.x |
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