Academic Journal
The role of regulatory T cells in allergic rhinitis and their correlation with IL-10, IL-17 and neopterin levels in serum and nasal lavage fluid
| العنوان: | The role of regulatory T cells in allergic rhinitis and their correlation with IL-10, IL-17 and neopterin levels in serum and nasal lavage fluid |
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| المؤلفون: | Erkan, Kadriye., Bozkurt, Mete K., Artaç, Hasibe., Özdemir, Hülya., Ünlü, Ali., Korucu, Emine N., Elsürer, Çağdaş. |
| المساهمون: | Selçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, orcid:0000-0002-5022-6927, Bozkurt, Mete K., Artaç, Hasibe., Özdemir, Hülya., Ünlü, Ali., Elsürer, Çağdaş. |
| بيانات النشر: | SPRINGER |
| سنة النشر: | 2020 |
| المجموعة: | Selçuk Üniversitesi: SÜ Sosyal Bilimler Enstitüsü - Dergisi Açık Arşivi |
| مصطلحات موضوعية: | Allergic rhinitis, Regulatory T cells, IL-10, IL-17, Neopterin |
| الوصف: | WOS: 000515628000003 ; PubMed: 31993765 ; Purpose Allergic rhinitis (AR), is an IgE-mediated inflammation of the nose. Regulatory T cells (Tregs) and inflammatory cytokines have been shown to play a critical role in allergic airway inflammation. The aim of the study was to compare the levels of blood T lymphocyte subsets and IL-10, IL-17 and neopterin concentrations in serum and nasal lavage of patients with AR compared to healthy subjects. Methods The study included 38 subjects with moderate-severe AR and 36 sex- and age-matched controls. Peripheral blood CD3+, CD3+CD4+ and CD4+CD25+Foxp3 percentages were evaluated using flow cytometry. Levels of IL-10, IL-17 and neopterin were measured both in serum and nasal lavage fluid with ELISA and HPLC, respectively. Results No difference was found in the percentages of T lymphocyte subsets between the two groups (p > 0.05). Serum IL-10 levels were similar (p > 0.05), whereas nasal IL-10 was lower in AR subjects compared to control group (2.22 +/- 0.91 and 3.12 +/- 1.45 pg/ml, respectively) (p < 0.05). Mean serum and nasal IL-17 were higher in AR (107.7 +/- 79.61 and 527.36 +/- 738.7 pg/ml) than the control group (76.29 +/- 28.94 and 328.9 +/- 430.8 pg/ml) (p < 0.05 and p > 0.05). There were no significant differences in serum and nasal neopterin levels (p > 0.05). Conclusions Although there were no differences in the distribution of lymphocyte subsets between the AR and control groups, the finding of higher levels of serum and nasal IL-17 and lower levels of nasal IL-10 support the cytokine imbalance in the pathogenesis of AR. ; Selcuk Universitesi [15102018] |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0937-4477 1434-4726 |
| Relation: | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Erkan, K., Bozkurt, M. K., Artaç, H., Özdemir, H., Ünlü, A., Korucu, E. N., Elsürer, Ç. (2020). The Role of Regulatory T Cells in Allergic Rhinitis and Their Correlation with IL-10, IL-17 and Neopterin Levels in Serum and Nasal Lavage Fluid. European Archives of Oto-Rhino-Laryngology, 277(4), 1109-1114.; https://dx.doi.org/10.1007/s00405-020-05811-4; https://hdl.handle.net/20.500.12395/38323; 277; 1109; 1114 |
| DOI: | 10.1007/s00405-020-05811-4 |
| الاتاحة: | https://hdl.handle.net/20.500.12395/38323 https://doi.org/10.1007/s00405-020-05811-4 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3317B84B |
| قاعدة البيانات: | BASE |
| تدمد: | 09374477 14344726 |
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| DOI: | 10.1007/s00405-020-05811-4 |