Academic Journal
Spef1/CLAMP binds microtubules and actin‐based structures and regulates cell migration and epithelia cell polarity
| العنوان: | Spef1/CLAMP binds microtubules and actin‐based structures and regulates cell migration and epithelia cell polarity |
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| المؤلفون: | Tapia, Rocio, Hecht, Gail A. |
| المصدر: | Annals of the New York Academy of Sciences ; volume 1515, issue 1, page 97-104 ; ISSN 0077-8923 1749-6632 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | During migration, cells invade, repair, and create barriers leading to the formation of new cellular contacts in target tissues. Cell migration requires many proteins that collectively form the cytoskeleton. The main cytoskeletal elements are actin filaments, microtubules (MTs), and intermediate filaments. These structures work in concert with a large number of accessory proteins that contribute in a variety of ways to regulate filament assembly and turnover, to alter the configuration or arrangement of filaments by bundling or crosslinking, to link the cytoskeleton to other structures in the cell, such as membranes and junctions, and to transport cargo along the filaments. Sperm flagella protein‐1 (Spef1), also designated calponin homology and microtubules‐associated protein (CLAMP), is a multifunctional protein that interacts with cytoskeletal structures, including MTs, actin filaments, and focal adhesions in epithelia. In this review, we outline Spef1/CLAMP structure and expression in several cellular models. The function of Spef1/CLAMP in flagellar and ciliary motility, MT‐binding and stability, regulation of planar cell polarity, and potential contribution to the maintenance of actin‐based structures, such as lamellipodia and filopodia during cell migration, are also discussed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/nyas.14845 |
| الاتاحة: | http://dx.doi.org/10.1111/nyas.14845 https://onlinelibrary.wiley.com/doi/pdf/10.1111/nyas.14845 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/nyas.14845 https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/nyas.14845 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.33140728 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/nyas.14845 |
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