Academic Journal
Synthesis and Antiproliferative Activity of 2-arylidene 6-(2-aryl-2-oxoethoxy) Benzofuran-3-one Derivatives
| العنوان: | Synthesis and Antiproliferative Activity of 2-arylidene 6-(2-aryl-2-oxoethoxy) Benzofuran-3-one Derivatives |
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| المؤلفون: | Demirayak, Şeref, Yurttaş, Leyla, Karaburun, Ahmet Çağrı, Gündoğdu-Karaburun, Nalan, Kayagil, İsmail |
| المساهمون: | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Demirayak, Şeref, Yurttaş, Leyla, Karaburun, Ahmet Çağrı, Gündoğdu-Karaburun, Nalan |
| بيانات النشر: | Bentham Science Publ LTD |
| سنة النشر: | 2016 |
| المجموعة: | Anadolu University Institutional Repository |
| مصطلحات موضوعية: | Antitumor Activity, Aurone, Benzofuranone, Chalcone, Cytotoxic Activity |
| الوصف: | WOS: 000389460600011 ; The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according to the drug screening protocol of the institute against approximately 60 tumor cell lines derived from nine cancer diseases. Compound 3r, namely 2-(4-chlorobenzylidene)- 6-[2-(4-methoxyphenyl)-2-oxoethoxy] benzofuran-3-one exhibited the highest antitumor activity against non-small lung cancer cell lines. ; Anadolu University, Turkey (BAP Project) [050301] ; The study was financially supported by Anadolu University, Turkey (BAP Project No: 050301). The authors present their thanks to NCI (USA) and Anadolu University BIBAM (Turkiye) for anticancer test results and NMR spectra, respectively. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1570-1808 1875-628X |
| Relation: | Letters in Drug Design & Discovery; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.2174/1570180813999160429113316; https://hdl.handle.net/11421/13645; 13; 563; 569 |
| DOI: | 10.2174/1570180813999160429113316 |
| الاتاحة: | https://hdl.handle.net/11421/13645 https://doi.org/10.2174/1570180813999160429113316 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.32EE4FF1 |
| قاعدة البيانات: | BASE |
| تدمد: | 15701808 1875628X |
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| DOI: | 10.2174/1570180813999160429113316 |