Academic Journal
Effect of cisplatin containing liposomes formulated by unsaturated chain-containing lipids on gynecological tumor cells
| العنوان: | Effect of cisplatin containing liposomes formulated by unsaturated chain-containing lipids on gynecological tumor cells |
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| المؤلفون: | RINGHIERI, PAOLA, Pannunzio, Alessandra, Boccarelli, Angelina, MORELLI, GIANCARLO, Coluccia, Mauro, TESAURO, DIEGO |
| المساهمون: | Ringhieri, Paola, Pannunzio, Alessandra, Boccarelli, Angelina, Morelli, Giancarlo, Coluccia, Mauro, Tesauro, Diego |
| سنة النشر: | 2016 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | CDDP, cisplatin, drug delivery, gynecological tumor, liposome |
| Time: | 3003 |
| الوصف: | Gynecological tumors are major therapeutic areas of platinum-based anticancer drugs. Here, we report the characterization and in vitro biological assays of cisplatin-containing Egg L-α-phosphatidylcholine liposomes with different amounts of cholesterol. Dynamic light scattering estimated sizes of all obtained liposomes in the 100 nm range that are suitable for in vivo use. On the basis of these data and of the drug loading values, the best formulation has been selected. Stability and drug release properties of platinum-containing liposomes have been verified in serum. The growth inhibitory effects of both liposomal and free drug in a panel of ovarian and breast human cancer cell lines, characterized by a different drug sensitivity, give comparable or better results with respect to free cisplatin drug. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000383903300006; volume:26; issue:4; firstpage:1; lastpage:6; numberofpages:6; journal:JOURNAL OF LIPOSOME RESEARCH; http://hdl.handle.net/11588/642537; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84958039992 |
| DOI: | 10.3109/08982104.2015.1127257 |
| الاتاحة: | http://hdl.handle.net/11588/642537 https://doi.org/10.3109/08982104.2015.1127257 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.32DAE74D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3109/08982104.2015.1127257 |
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