Academic Journal
Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice
| العنوان: | Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice |
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| المؤلفون: | Nickerson, Kevin M., Smita, Shuchi, Hoehn, Kenneth B., Marinov, Anthony D., Thomas, Kayla B., Kos, Justin T., Yang, Yi, Bastacky, Sheldon I., Watson, Corey T., Kleinstein, Steven H., Shlomchik, Mark J. |
| المساهمون: | National Institutes of Health, Lupus Research Alliance |
| المصدر: | Journal of Experimental Medicine ; volume 220, issue 5 ; ISSN 0022-1007 1540-9538 |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 2023 |
| الوصف: | Age-associated B cells (ABCs) are formed under inflammatory conditions and are considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE, ABC frequency is correlated with disease, and they are thought to be the source of autoantibody-secreting cells. However, in inflammatory conditions, whether autoreactive B cells can become resting MBCs is uncertain. Further, the phenotypic identity of ABCs and their relationship to other B cell subsets, such as plasmablasts, is unclear. Whether ABCs directly promote disease is untested. Here we report, in the MRL/lpr SLE model, unexpected heterogeneity among ABC-like cells for expression of the integrins CD11b and CD11c, T-bet, and memory or plasmablast markers. Transfer and labeling studies demonstrated that ABCs are dynamic, rapidly turning over. scRNA-seq identified B cell clones present in multiple subsets, revealing that ABCs can be plasmablast precursors or undergo cycles of reactivation. Deletion of CD11c-expressing B cells revealed a direct role for ABC-like B cells in lupus pathogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1084/jem.20221346 |
| DOI: | 10.1084/jem.20221346/1448273/jem_20221346.pdf |
| الاتاحة: | http://dx.doi.org/10.1084/jem.20221346 https://rupress.org/jem/article-pdf/doi/10.1084/jem.20221346/1448273/jem_20221346.pdf |
| Rights: | http://www.rupress.org/terms/ ; https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| رقم الانضمام: | edsbas.32C0EDEC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20221346 |
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