Academic Journal
Effectiveness of immunotherapies in relapsing myelin oligodendrocyte glycoprotein antibody-associated disease
| العنوان: | Effectiveness of immunotherapies in relapsing myelin oligodendrocyte glycoprotein antibody-associated disease |
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| المؤلفون: | Bilodeau, Philippe Antoine, Vishnevetsky, Anastasia, Molazadeh, Negar, Lotan, Itay, Anderson, Monique, Romanow, Gabriela, Salky, Rebecca, Healy, Brian C, Matiello, Marcelo, Chitnis, Tanuja, Levy, Michael |
| المصدر: | Multiple Sclerosis Journal ; volume 30, issue 3, page 357-368 ; ISSN 1352-4585 1477-0970 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2024 |
| الوصف: | Background: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) can cause optic neuritis, transverse myelitis, or acute disseminated encephalomyelitis (ADEM). Immunotherapy is often used for relapsing disease, but there is variability in treatment decisions. Objective: The objective was to determine the annualized relapse rates (ARRs) and incidence rate ratios (IRRs) compared to pre-treatment and relapse-freedom probabilities among patients receiving steroids, B-cell depletion (BCD), intravenous immunoglobulin (IVIG), and mycophenolate mofetil (MMF). Methods: Retrospective cohort study of patients with relapsing MOGAD treated at Mass General Brigham. ARRs and IRRs compared to pre-treatment, and relapse-freedom probability and odds ratio for relapse-freedom compared to prednisone were calculated. Results: A total of 88 patients met the inclusion criteria. The ARR on IVIG was 0.13 (95% confidence interval (CI) = 0.06–0.27) and the relapse-freedom probability after at least 6 months of therapy was 72%. The ARR on BCD was 0.51 (95% CI = 0.34–0.77), and the relapse-freedom probability was 33%. The ARR on MMF was 0.32 (95% CI = 0.19–0.53) and the relapse-freedom probability was 49%. In pediatric-onset disease, MMF had the lowest ARRs (0.15, 95% CI = 0.07–0.33). Conclusion: IVIG had the lowest ARRs and IRRs compared to pre-treatment and the highest relapse-freedom odds ratio compared to prednisone, while BCD had the lowest. In pediatric-onset MOGAD, MMF had the lowest ARRs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/13524585241226830 |
| الاتاحة: | http://dx.doi.org/10.1177/13524585241226830 https://journals.sagepub.com/doi/pdf/10.1177/13524585241226830 https://journals.sagepub.com/doi/full-xml/10.1177/13524585241226830 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.3293CF6D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/13524585241226830 |
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