Academic Journal
Spherization of red blood cells and platelet margination in COPD patients
| العنوان: | Spherization of red blood cells and platelet margination in COPD patients |
|---|---|
| المؤلفون: | Zouaoui Boudjeltia, Karim, Kotsalos, Christos, Ribeiro De Sousa, Daniel, Rousseau, Alexandre, Lelubre, Christophe, Sartenaer, Olivier, Piagnerelli, Michaël, Dohet-Eraly, Jérôme, Dubois, Frank, Tasiaux, Nicole, Chopard, Bastien, Van Meerhaeghe, Alain |
| المصدر: | Annals of the New York Academy of Sciences, 1485 (1 |
| سنة النشر: | 2020 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Sciences bio-médicales et agricoles, Sciences exactes et naturelles, red blood cells, platelet transport, COPD, numerical simulation |
| الوصف: | Red blood cells (RBCs) in pathological situations undergo biochemical and conformational changes, leading to alterations in rheology involved in cardiovascular events. The shape of RBCs in volunteers and stable and exac- erbated chronic obstructive pulmonary disease (COPD) patients was analyzed. The effects of RBC spherization on platelet transport (displacement in the flow field caused by their interaction with RBCs) were studied in vitro and by numerical simulations. RBC spherization was observed in COPD patients compared with volunteers. In in vitro experiments at a shear rate of 100 s−1, treatment of RBCs with neuraminidase induced greater sphericity, which mainly affected platelet aggregates without changing aggregate size. At 400 s−1, neuraminidase treatment changes both the size of the aggregates and the number of platelet aggregates. Numerical simulations indicated that RBC spherization induces an increase of the platelet mean square displacement, which is traditionally linked to the platelet diffusion coefficient. RBCs of COPD patients are more spherical than healthy volunteers. Experimentally, RBC spherization induces increased platelet transport to the wall. Additional studies are needed to understand the link between the effect of RBCs on platelet transport and the increased cardiovascular events observed in COPD patients. ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 2 full-text file(s): application/pdf | application/pdf |
| اللغة: | English |
| Relation: | uri/info:doi/doi:10.1111/nyas.14489; https://dipot.ulb.ac.be/dspace/bitstream/2013/318194/3/2021-AnnNYAcadSci-1485-BPCO.pdf; https://dipot.ulb.ac.be/dspace/bitstream/2013/318194/4/BPCO-MedRxiv_VersionPreprint.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/318194 |
| الاتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/318194 https://dipot.ulb.ac.be/dspace/bitstream/2013/318194/3/2021-AnnNYAcadSci-1485-BPCO.pdf https://dipot.ulb.ac.be/dspace/bitstream/2013/318194/4/BPCO-MedRxiv_VersionPreprint.pdf |
| رقم الانضمام: | edsbas.32846CAC |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |