Academic Journal
Compromised dental cells viability following teeth-whitening exposure
| العنوان: | Compromised dental cells viability following teeth-whitening exposure |
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| المؤلفون: | Redha, O., Mazinanian, M., Nguyen, S., Son, D.O., Lodyga, M., Hinz, B., Odlyha, Marianne, McDonald, A., Bozec, L. |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2021 |
| المجموعة: | Birkbeck University of London: BIROn - Birkbeck Institutional Research Online |
| مصطلحات موضوعية: | Biological Sciences |
| الوصف: | This study aimed to assess the viability of dental cells following time-dependent carbamide peroxide teeth-whitening treatments using an in-vitro dentin perfusion assay model. 30 teeth were exposed to 5% or 16% CP gel (4 h daily) for 2-weeks. The enamel organic content was measured with thermogravimetry. The time-dependent viability of human dental pulp stem cells (HDPSCs) and gingival fibroblast cells (HGFCs) following either indirect exposure to 3 commercially available concentrations of CP gel using an in-vitro dentin perfusion assay or direct exposure to 5% H2O2 were investigated by evaluating change in cell morphology and by hemocytometry. The 5% and 16% CP produced a significantly lower (p < 0.001) enamel protein content (by weight) when compared to the control. The organic content in enamel varied accordingly to the CP treatment: for the 16% and 5% CP treatment groups, a variation of 4.0% and 5.4%, respectively, was observed with no significant difference. The cell viability of HDPSCs decreased exponentially over time for all groups. Within the limitation of this in-vitro study, we conclude that even low concentrations of H2O2 and CP result in a deleterious change in enamel protein content and compromise the viability of HGFCs and HDPSCs. These effects should be observed in-vivo. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://eprints.bbk.ac.uk/id/eprint/45387/1/45387.pdf; Redha, O. and Mazinanian, M. and Nguyen, S. and Son, D.O. and Lodyga, M. and Hinz, B. and Odlyha, Marianne and McDonald, A. and Bozec, L. (2021) Compromised dental cells viability following teeth-whitening exposure. Scientific Reports 11 (1), p. 15547. ISSN 2045-2322. |
| DOI: | 10.1038/s41598-021-94745-w |
| الاتاحة: | https://eprints.bbk.ac.uk/id/eprint/45387/ https://eprints.bbk.ac.uk/id/eprint/45387/1/45387.pdf https://doi.org/10.1038/s41598-021-94745-w |
| Rights: | cc_by_4 |
| رقم الانضمام: | edsbas.325EAB81 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-021-94745-w |
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