Academic Journal
Endothelial dysfunction in acute and chronic coronary syndromes: evidence for a pathogenetic role of oxidative stress
| العنوان: | Endothelial dysfunction in acute and chronic coronary syndromes: evidence for a pathogenetic role of oxidative stress |
|---|---|
| المؤلفون: | VALGIMIGLI, Marco, MALAGUTTI, Patrizia, FERRARI, Roberto, MERLI E, SOUKHOMOVSKAIA O, CICCHITELLI G, MACRI G |
| المساهمون: | Valgimigli, Marco, Merli, E, Malagutti, Patrizia, Soukhomovskaia, O, Cicchitelli, G, Macri, G, Ferrari, Roberto |
| سنة النشر: | 2003 |
| المجموعة: | Università degli Studi di Ferrara: CINECA IRIS |
| الوصف: | The past two decades have highlighted the pivotal role of the endothelium in preserving vascular homeostasis. Among others, nitric oxide (NO) is currently believed to be the main component responsible for endothelium dependent vasorelaxation and therefore for endothelial function integrity. Reduced NO bioavailability causes the so-called "endothelial dysfunction," which seems to be the common molecular disorder comprising stable atherosclerotic narrowing lesions or acute plaque rupture causing unstable angina or myocardial infarction. Compelling evidence is accumulating, stressing the role of oxidative stress in causing reduced NO bioavailability and subsequently endothelial dysfunction (ED). More recently, the role of endothelial cell (EC) apoptosis as a possible final stage of ED and plaque activation has been suggested. In vitro and in vivo evidence suggests a role of oxidative stress also as a putative mechanism finally leading to plaque denudation and activation through increased EC apoptosis. Thus, oxidative stress, irrespective of atherosclerotic disease stages, seems to represent a key phenomenon in vascular disease progression and possible prevention. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000187459000007; volume:420; issue:2; firstpage:255; lastpage:261; journal:ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; http://hdl.handle.net/11392/1202731; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0345356543 |
| DOI: | 10.1016/j.abb.2003.07.006 |
| الاتاحة: | http://hdl.handle.net/11392/1202731 https://doi.org/10.1016/j.abb.2003.07.006 |
| رقم الانضمام: | edsbas.324113E2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.abb.2003.07.006 |
|---|