Academic Journal
Parsimonious modeling of skeletal muscle perfusion: connecting the stretched exponential and fractional Fickian diffusion
| العنوان: | Parsimonious modeling of skeletal muscle perfusion: connecting the stretched exponential and fractional Fickian diffusion |
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| المؤلفون: | Reiter, D.A., Adelnia, F., Cameron, D., Spencer, R.G., Ferrucci, L. |
| المصدر: | Magnetic Resonance in Medicine |
| سنة النشر: | 2021 |
| المجموعة: | Leiden Repository (Leiden University) |
| مصطلحات موضوعية: | anomalous diffusion, fractional calculus, hyperemia, intravoxel incoherent motion, microvascular volume, superdiffusion |
| الوصف: | Purpose To develop an anomalous (non-Gaussian) diffusion model for characterizing skeletal muscle perfusion using multi-b-value DWI.Theory and methods Fick's first law was extended for describing tissue perfusion as anomalous superdiffusion, which is non-Gaussian diffusion exhibiting greater particle spread than that of the Gaussian case. This was accomplished using a space-fractional derivative that gives rise to a power-law relationship between mean squared displacement and time, and produces a stretched exponential signal decay as a function of b-value. Numerical simulations were used to estimate parameter errors under in vivo conditions, and examine the effect of limited SNR and residual fat signal. Stretched exponential DWI parameters, alpha and D, were measured in thigh muscles of 4 healthy volunteers at rest and following in-magnet exercise. These parameters were related to a stable distribution of jump-length probabilities and used to estimate microvascular volume fractions.Results Numerical simulations showed low dispersion in parameter estimates within 1.5% and 1%, and bias errors within 3% and 10%, for alpha and D, respectively. Superdiffusion was observed in resting muscle, and to a greater degree following exercise. Resting microvascular volume fraction was between 0.0067 and 0.0139 and increased between 2.2-fold and 4.7-fold following exercise.Conclusions This model captures superdiffusive molecular motions consistent with perfusion, using a parsimonious representation of the DWI signal, providing approximations of microvascular volume fraction comparable with histological estimates. This signal model demonstrates low parameter-estimation errors, and therefore holds potential for a wide range of applications in skeletal muscle and elsewhere in the body. ; Radiology |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://ueaeprints.uea.ac.uk/id/eprint/79760/1/Perfusion_Measured_With_Anomalous_Diffusion_Modeling.pdf; lumc-id: 122563646; https://hdl.handle.net/1887/3277566 |
| DOI: | 10.1002/mrm.28766 |
| الاتاحة: | https://hdl.handle.net/1887/3277566 https://ueaeprints.uea.ac.uk/id/eprint/79760/1/Perfusion_Measured_With_Anomalous_Diffusion_Modeling.pdf https://doi.org/10.1002/mrm.28766 |
| رقم الانضمام: | edsbas.321A93 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/mrm.28766 |
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