Academic Journal
Redox Chemistry: Implications for Necrotizing Enterocolitis
| العنوان: | Redox Chemistry: Implications for Necrotizing Enterocolitis |
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| المؤلفون: | Grant H. Gershner, Catherine J. Hunter |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 15, p 8416 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | oxidative stress, necrotizing enterocolitis, neonate, prematurity, reactive oxygen species, reactive nitrogen species, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Reduction–oxidation (redox) chemistry plays a vital role in human homeostasis. These reactions play critical roles in energy generation, as part of innate immunity, and in the generation of secondary messengers with various functions such as cell cycle progression or the release of neurotransmitters. Despite this cornerstone role, if left unchecked, the body can overproduce reactive oxygen species (ROS) or reactive nitrogen species (RNS). When these overwhelm endogenous antioxidant systems, oxidative stress (OS) occurs. In neonates, OS has been associated with retinopathy of prematurity (ROP), leukomalacia, and bronchopulmonary dysplasia (BPD). Given its broad spectrum of effects, research has started to examine whether OS plays a role in necrotizing enterocolitis (NEC). In this paper, we will discuss the basics of redox chemistry and how the human body keeps these in check. We will then discuss what happens when these go awry, focusing mostly on NEC in neonates. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/15/8416; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/e2a4c46427a941aeb5ca588d02b2e389 |
| DOI: | 10.3390/ijms25158416 |
| الاتاحة: | https://doi.org/10.3390/ijms25158416 https://doaj.org/article/e2a4c46427a941aeb5ca588d02b2e389 |
| رقم الانضمام: | edsbas.3214B09C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25158416 |